(Q35025021)

5 August 2017

title

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers (English)

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16

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F F Wagner

1

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Y-L Zhang

2

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D M Fass

3

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N Joseph

4

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J P Gale

5

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M Weïwer

6

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P McCarren

7

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S L Fisher

8

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T Kaya

9

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W-N Zhao

10

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S A Reis

11

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K M Hennig

12

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M Thomas

13

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B C Lemercier

14

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M C Lewis

15

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M P Moyer

17

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E Scolnick

18

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L-H Tsai

20

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E B Holson

21

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5 August 2017

publication date

1 January 2015

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5 August 2017

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5 August 2017

volume

6

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5 August 2017

issue

1

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5 August 2017

page(s)

804-815

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describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4310013/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

8 July 2018

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Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia

8 July 2018

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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

8 July 2018

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Class I HDAC imaging using [ (3)H]CI-994 autoradiography

8 July 2018

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Loss of histone deacetylase 2 improves working memory and accelerates extinction learning

8 July 2018

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HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

8 July 2018

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The potential of HDAC inhibitors as cognitive enhancers.

8 July 2018

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Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

8 July 2018

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Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

8 July 2018

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

8 July 2018

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Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

8 July 2018

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HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases

8 July 2018

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Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

8 July 2018

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Epigenetic regulation in substance use disorders

8 July 2018

1 reference

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Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

8 July 2018

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Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

8 July 2018

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Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with histone deacetylase inhibitors

8 July 2018

1 reference

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HDAC2 negatively regulates memory formation and synaptic plasticity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell.

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Distribution of histone deacetylases 1-11 in the rat brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Drug-target residence time and its implications for lead optimization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310013

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC02130D

Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC02130D

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC4SC02130D

Pharmacokinetics and cerebrospinal fluid penetration of CI-994 (N-acetyldinaline) in the nonhuman primate

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25642316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25642316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C4SC02130D

1 reference

5 August 2017

1 reference

5 August 2017

1 reference