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Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)
scientific article published on November 2011
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Europe PubMed Central
PMCID
3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
title
Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)
(English)
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stated in
Europe PubMed Central
PMCID
3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
main subject
neurodegeneration
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author
Paola Giusti-Rodríguez
series ordinal
1
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Europe PubMed Central
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3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Johannes Gräff
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3
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Europe PubMed Central
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3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
Takahiro Soda
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5
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3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
Li-Huei Tsai
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6
object named as
Li-Huei Tsai
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Europe PubMed Central
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3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
author name string
Jun Gao
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2
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Europe PubMed Central
PMCID
3248793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Damien Rei
series ordinal
4
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Europe PubMed Central
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3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
language of work or name
English
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publication date
1 November 2011
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3248793
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retrieved
15 January 2020
published in
Journal of Neuroscience
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3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
volume
31
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Europe PubMed Central
PMCID
3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
issue
44
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Europe PubMed Central
PMCID
3248793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
page(s)
15751-15756
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Europe PubMed Central
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3248793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.
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CDK5 serves as a major control point in neurotransmitter release.
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In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
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25 September 2018
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
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Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.
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25 September 2018
Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.
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25 September 2018
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248793
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25 September 2018
Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.
1 reference
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25 September 2018
Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22049418
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22049418
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1523/JNEUROSCI.3588-11.2011
1 reference
stated in
Europe PubMed Central
PMCID
3248793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PMCID
3248793
1 reference
stated in
Europe PubMed Central
PMCID
3248793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PubMed ID
22049418
1 reference
stated in
Europe PubMed Central
PMCID
3248793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22049418%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
ResearchGate publication ID
51766387
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