(Q35026401)

5 August 2017

1 reference

title

RecQ family helicases: roles as tumor suppressor proteins (English)

1 reference

5 August 2017

Hiroaki Nakayama

1

1 reference

5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

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5 August 2017

volume

21

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5 August 2017

issue

58

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5 August 2017

page(s)

9008-9021

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Hypoxia links ATR and p53 through replication arrest

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

Radiation effects on DNA synthesis in a defined chromosomal replicon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Circles: the replication-recombination-chromosome segregation connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Regulation and localization of the Bloom syndrome protein in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Physical and functional interaction between p53 and the Werner's syndrome protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

p53 Modulates the exonuclease activity of Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Functional and physical interaction between WRN helicase and human replication protein A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Differential expression of p53, p21waf1/cip1 and hdm2 dependent on DNA damage in Bloom's syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Therefore, what are recombination proteins there for?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

RecQ and RecJ process blocked replication forks prior to the resumption of replication in UV-irradiated Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Historical overview: searching for replication help in all of the rec places

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Molecular genetics of Bloom's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's syndrome gene product is homologous to RecQ helicases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The gene responsible for Werner syndrome may be a cell division "counting" gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Ku, a DNA repair protein with multiple cellular functions?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Genetic recombination in Bacillus subtilis 168: effects of recU and recS mutations on DNA repair and homologous recombination.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Mutator phenotype of Werner syndrome is characterized by extensive deletions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Spontaneous and induced chromosomal instability in Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Bloom's syndrome. XX. The first 100 cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Immunological abnormalities of aging: an analysis of T lymphocyte subpopulations of Werner's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Reduced Natural Killer Cell Activity of Lymphocytes from Patients with Werner's Syndrome and Recovery of Its Activity by Purified Human Leucocyte Interferon

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Werner syndrome protein is a DNA helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Bloom's syndrome. XVIII. Hypermutability at a tandem-repeat locus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Animal models of tumor-suppressor genes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Biochemical characterization of the DNA helicase activity of the escherichia coli RecQ helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Molecular characterisation of RecQ homologues in Arabidopsis thaliana.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

SGS1 is required for telomere elongation in the absence of telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The recQ gene of Escherichia coli K12: primary structure and evidence for SOS regulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Identification of Drosophila melanogaster RECQE as a member of a new family of RecQ homologues that is preferentially expressed in early embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's syndrome gene product is a 3'-5' DNA helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's syndrome gene product promotes branch migration of holliday junctions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Differential regulation of human RecQ family helicases in cell transformation and cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Telomeres, aging and cancer: in search of a happy ending

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Cancer-susceptibility genes. Gatekeepers and caretakers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Functional interaction between Ku and the werner syndrome protein in DNA end processing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Human homologues of yeast helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Rescue of arrested replication forks by homologous recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Nucleotide sequence analysis of human hypoxanthine phosphoribosyltransferase (HPRT) gene deletions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K12: identification of a new mutation (recQ1) that blocks the RecF recombination pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Defending genome integrity during S-phase: putative roles for RecQ helicases and topoisomerase III.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Loss of Werner syndrome protein function promotes aberrant mitotic recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

p53-mediated apoptosis is attenuated in Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The contribution of homologous recombination in preserving genome integrity in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The N-terminal region of Sgs1, which interacts with Top3, is required for complementation of MMS sensitivity and suppression of hyper-recombination in sgs1 disruptants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

RecQ DNA helicase of Escherichia coli. Characterization of the helix-unwinding activity with emphasis on the effect of single-stranded DNA-binding protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Escherichia coli RecQ protein is a DNA helicase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Bloom's syndrome. Clinical features and immunologic abnormalities of four patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Possible association of BLM in decreasing DNA double strand breaks during DNA replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Functional interaction of p53 and BLM DNA helicase in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

The Bloom's syndrome gene product interacts with topoisomerase III

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Replication focus-forming activity 1 and the Werner syndrome gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205959

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205959

1 reference

5 August 2017

1 reference