(Q35029194)

English

In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

based on heuristic

inferred from title

tumour xenograft

1 reference

based on heuristic

inferred from title

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

object named as

Kees Fluiter

8

0 references

Jyoti Chattopadhyaya

object named as

Jyoti Chattopadhyaya

6

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object named as

Jesper Wengel

4

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author name string

Orf Mook

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Jeroen Vreijling

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Suzy L Wengel

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Chuanzheng Zhou

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 July 2010

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Artificial DNA, PNA & XNA

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

36-44

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

RNAi-based therapeutics-current status, challenges and prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

MicroRNA-like off-target transcript regulation by siRNAs is species specific.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Improved silencing properties using small internally segmented interfering RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Activation of the mammalian immune system by siRNAs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Silencing of CXCR4 blocks breast cancer metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Tritium labeling of antisense oligonucleotides by exchange with tritiated water

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

Genomic sequencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

8 July 2018

UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Experimental validation of the importance of seed complement frequency to siRNA specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Tumor genotype-specific growth inhibition in vivo by antisense oligonucleotides against a polymorphic site of the large subunit of human RNA polymerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109444

25 October 2018

Five- and Six-Membered Conformationally Locked 2‘,4‘-Carbocyclicribo-Thymidines: Synthesis, Structure, and Biochemical Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21687525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/21687525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: Introduction of three novel analogues and a summary

1 reference

https://pubmed.ncbi.nlm.nih.gov/21687525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-(4-Tolylsulfonyl)ethoxymethyl (TEM)—a new 2′-OH protecting group for solid-supported RNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21687525

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/ADNA.1.1.12204

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

release_eoptqkzxojholcgtst5jzg4y3a

1 reference

https://api.fatcat.wiki/v0/release/eoptqkzxojholcgtst5jzg4y3a

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

0 references

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