(Q35030777)

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Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548574%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex (English)

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30 January 2020

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30 January 2020

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Neil Osheroff

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30 January 2020

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Steven L Pitts

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30 January 2020

Michael J Jablonksy

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30 January 2020

Maria Duca

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30 January 2020

Daniel Dauzonne

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30 January 2020

Claude Monneret

5

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30 January 2020

Paola B Arimondo

6

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30 January 2020

David E Graves

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30 January 2020

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13 May 2011

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30 January 2020

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30 January 2020

50

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30 January 2020

22

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30 January 2020

5058-5066

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30 January 2020

Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Targeting DNA topoisomerase II in cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

DNA topoisomerase II, genotoxicity, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Interfacial inhibitors of protein-nucleic acid interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Etoposide, topoisomerase II and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Synthesis and antiproliferative activity of retroetoposide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Apoptosis induced by topoisomerase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

DNA topoisomerases as anticancer drug targets: from the laboratory to the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

A two-drug model for etoposide action against human topoisomerase IIalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

DNA topoisomerases: structure, function, and mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Etoposide: four decades of development of a topoisomerase II inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Mutagenic properties of topoisomerase-targeted drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Analysis of topoisomerase I/DNA complexes in patients administered topotecan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

A role for the passage helix in the DNA cleavage reaction of eukaryotic topoisomerase II. A two-site model for enzyme-mediated DNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

8 July 2018

Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

25 October 2018

A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

25 October 2018

DNA sequence selectivity of topoisomerases and topoisomerase poisons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

25 October 2018

Apurinic sites are position-specific topoisomerase II poisons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

25 October 2018

A temperature sensitive topoisomerase II allele confers temperature dependent drug resistance on amsacrine and etoposide: a genetic system for determining the targets of topoisomerase II inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109987

25 October 2018

Dexrazoxane for protection against cardiotoxic effects of anthracyclines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical applications of anticancer drugs targeted to topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death induced by topoisomerase-targeted drugs: more questions than answers

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

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Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20

1 reference

https://pubmed.ncbi.nlm.nih.gov/21548574

12 December 2020

based on heuristic

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10.1021/BI200531Q

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Europe PubMed Central

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30 January 2020

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Europe PubMed Central

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30 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21548574%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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