(Q35035039)

5 August 2017

5 references

6 August 2019

28 September 2019

9 October 2019

18 November 2019

14 December 2019

Role of cytochrome P-450 and related enzymes in the pulmonary metabolism of xenobiotics (English)

1 reference

pharmaceutical preparation

5 August 2017

main subject

1 reference

6 August 2019

1 reference

28 September 2019

1 reference

9 October 2019

1 reference

18 November 2019

1 reference

14 December 2019

R. M. Philpot

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6376107

11 October 2023

B. R. Smith

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6376107

11 October 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6376107

11 October 2023

publication date

1 April 1984

6 references

5 August 2017

6 August 2019

28 September 2019

9 October 2019

18 November 2019

14 December 2019

9

1 reference

full work available at URL

inferred from page(s)

https://doi.org/10.1289/ehp.8455359

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6376107

https://europepmc.org/articles/PMC1568372

11 October 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6376107

https://europepmc.org/articles/PMC1568372?pdf=render

11 October 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6376107

https://ehp.niehs.nih.gov/doi/pdf/10.1289/ehp.8455359

11 October 2023

1 reference

https://api.crossref.org/works/10.1289/EHP.8455359

Environmental Health Perspectives

11 October 2023

published in

6 references

5 August 2017

6 August 2019

28 September 2019

9 October 2019

18 November 2019

14 December 2019

55

1 reference

5 August 2017

page(s)

359-367

1 reference

Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Cytochrome p-450: localization in rabbit lung

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

The Role of Glutathione and Glutathione S-Transferases in Mercapturic Acid Biosynthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Arene oxides: a new aspect of drug metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

K-region epoxides of polycyclic hydrocarbons: Formation and further metabolism of benz[a] anthracene 5, 6-oxide by human lung preparations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Carcinogenic polynuclear hydrocarbons bind to macromolecules in cultured human bronchi.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Possible mechanism of liver necrosis caused by aromatic organic compounds

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Genetic differences in 2-acetylaminofluorene mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by polycyclic aromatic compounds

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4,5-epoxide as a metabolite of benzo(a)pyrene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Covalent interaction of carcinogens with DNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

The involvement of a diol-epoxide in the metabolic activation of benzo(a)pyrene in human bronchial mucosa and in mouse skin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Metabolism of (3H)benzo(a)pyrene by different portions of the respiratory tract

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Metabolic activation of benzo(a)pyrene and binding to DNA in cultured human bronchus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Metabolism of benzo(a)pyrene and its major metabolites to ethyl acetate-soluble and water-soluble metabolites by cultured rodent trachea

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Arachidonic acid-dependent metabolism of (±)trans-7,8-dihydroxy-7,8- dihydro-benzo[a]pyrene (BP-7,8 diol) to 7,10/8,9 tetrols

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Large interindividual variations in metabolism of benzo(α)pyrene by peripheral lung tissue from lung cancer patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Prostagland in synthetase dependent benzo(a)pyrene oxidation: Products of the oxidation and inhibition of their formation by antioxidants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured human bronchus and pancreatic duct

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Resolution of two forms of cytochrome P-450 from liver microsomes of rabbit treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

The role of cytochrome P-450 forms in 2-aminoanthracene and benz[α]pyrene mutagenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Peroxidatic oxidation of benzo[a]pyrene and prostaglandin biosynthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Metabolism of benzo (a) pyrene to reactive intermediate (S) via prostaglandin biosynthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Stimulatory effect of cigarette smoke on the metabolism and covalent binding of benzo(a)pyrene in the trachea of the rat.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

The rabbit pulmonary monooxygenase system: Characteristics and activities of two forms of pulmonary cytochrome P-450

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Foreign compound metabolism by isolated cells from rabbit lung

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

The biotransformation of p-xylene to a toxic aldehyde

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Hepatic and extrahepatic metabolism, in vitro, of an epoxide (8-14C-styrene oxide) in the rabbit

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Purification and structural comparison of pulmonary and hepatic cytochrome P-450 from rabbits.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Covalent binding of metabolites of 4-ipomeanol to rabbit pulmonary and hepatic microsomal proteins and to the enzymes of the pulmonary cytochrome P-450-dependent monooxygenase system.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Specificity of rabbit pulmonary cytochrome P-450 isozymes in the activation of several aromatic amines and aflatoxin B1.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Cigarette smoke: Stimulatory effect on metabolism of 3,4-benzpyrene by enzymes in rat lung

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1568372

Experimental cancer of the lung in rabbits induced by chemical carcinogens

25 October 2018

1 reference

12 December 2020

Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver

1 reference

12 December 2020

Rapid development of bronchiolo-alveolar squamous cell tumors in rats after intratracheal injection of 3-methylcholanthrene

1 reference

12 December 2020

Effect of exposure to cigarette smoke on the metabolism of benzo6a9pyrene and acetophenetidin by lung and intestine of rats

1 reference

12 December 2020

Formation of K-region epoxides as microsomal metabolites of pyrene and benzo(a)pyrene

1 reference

12 December 2020

Enzymatic conjugation of epoxides with glutathione

1 reference

12 December 2020

Characterization of lung microsomes as related to drug metabolism

1 reference

12 December 2020

Cytochrome P-450 purified to apparent homogeneity from phenobarbital-induced rabbit liver microsomes: catalytic activity and other properties

1 reference

12 December 2020

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1 reference

12 December 2020

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes

1 reference

12 December 2020

Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid

1 reference

12 December 2020

Benzo(a)pyren-3-yl hydrogen sulphate, a major ethyl acetate-extractable metabolite of benzo(a)pyrene in human, hamster and rat lung cultures

1 reference

12 December 2020

Metabolism and covalent binding of [3H]benzo(a)pyrene by isolated perfused lungs and short-term tracheal organ culture of cigarette smoke-exposed rats

1 reference

12 December 2020

The metabolism of benzo(a)pyrene, 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene and 9,10-dihydro-9,10-dihydroxybenzono leads to (a)pyrene by short-term organ cultures of hamster lung

1 reference

12 December 2020

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

1 reference

12 December 2020

Metabolism of benzo(a)pyrene by human lung microsomal fractions

1 reference

12 December 2020

Explant culture of human peripheral lung. I. Metabolism of benzo[alpha]pyrene

1 reference

12 December 2020

3HBenzo(a)pyrene metabolism in tracheal epithelial microsomes and tracheal organ cultures

1 reference

12 December 2020

Interaction of 4-methylbenzaldehyde with rabbit pulmonary cytochrome P-450 in the intact animal, microsomes, and purified systems. Destructive and protective reactions

1 reference

12 December 2020

Metabolism and covalent binding of benzo[a]pyrene in human peripheral lung

1 reference

12 December 2020

Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450

1 reference

12 December 2020

The rabbit pulmonary monooxygenase system. partial structural characterization of the cytochrome P-450 components and comparison to the hepatic cytochrome P-450

1 reference

12 December 2020

Differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin of multiple forms of rabbit microsomal cytochrome P-450: evidence for tissue specificity

1 reference

12 December 2020

Prostaglandin synthetase-dependent cooxidation of (+/-)-benzo(a)pyrene-7,8-dihydrodiol by human lung and other mammalian tissues

1 reference

12 December 2020

Selective loss of pulmonary cytochrome P-450I in rabbits pretreated with polychlorinated biphenyls

1 reference

12 December 2020

Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung

1 reference

12 December 2020

Effect of butylated hydroxyanisole, alpha-angelica lactone, and beta-naphthoflavone on benzo(alpha)pyrene:DNA adduct formation in vivo in the forestomach, lung, and liver of mice

1 reference

12 December 2020

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver

1 reference

12 December 2020

Pulmonary cytochromes P-450 from rabbits treated with 3-methylcholanthrene

1 reference

12 December 2020

The relationship between the catalytic activities of rabbit pulmonary cytochrome P-450 isozymes and the lung-specific toxicity of the furan derivative, 4-ipomeanol

1 reference

12 December 2020

The relationship between increases in the hepatic content of cytochrome P-450, form 5, and in the metabolism of aromatic amines to mutagenic products following treatment of rabbits with phenobarbital

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.8455359

1 reference

5 August 2017

1 reference

5 August 2017

1 reference