(Q35044088)

6 August 2017

title

HIV-1 Fitness and Replication Capacity: What Are They and Can They Help in Patient Management? (English)

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6 August 2017

1

Frank Maldarelli

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6 August 2017

language of work or name

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1 February 2003

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Current infectious disease reports

6 August 2017

published in

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6 August 2017

volume

5

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6 August 2017

issue

1

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6 August 2017

page(s)

77-84

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A novel recombinant marker virus assay for comparing the relative fitness of hiv-1 reverse transcriptase variants

6 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11908-003-0068-9

The replicative capacity of rhesus macaque peripheral blood mononuclear cells for simian immunodeficiency virus in vitro is predictive of the rate of progression to AIDS in vivo

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11908-003-0068-9

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

21 January 2018

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12 December 2020

Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an In vitro competitive HIV-1 replication assay

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12 December 2020

HIV accessory proteins: multifunctional components of a complex system.

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12 December 2020

Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants

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12 December 2020

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase

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12 December 2020

Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology.

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12 December 2020

Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: role of changes in thymic output and T cell death

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12 December 2020

Impaired replication of protease inhibitor-resistant HIV-1 in human thymus.

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12 December 2020

HIV drug resistance and viral fitness.

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12 December 2020

Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection

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12 December 2020

Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.

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12 December 2020

Altered viral fitness of HIV-1 following failure of protease inhibitor-based therapy

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12 December 2020

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

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12 December 2020

Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites

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12 December 2020

Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance.

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12 December 2020

A nucleotide substitution in the tRNA(Lys) primer binding site dramatically increases replication of recombinant simian immunodeficiency virus containing a human immunodeficiency virus type 1 reverse transcriptase

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12 December 2020

Effects of reverse-transcriptase mutations M184V and E89G on simian immunodeficiency virus in Rhesus monkeys

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12 December 2020

Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice

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12 December 2020

Estimating relative fitness in viral competition experiments.

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12 December 2020

Mathematical models of HIV pathogenesis and treatment

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12 December 2020

Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants

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12 December 2020

Primary and recombinant HIV type 1 strains resistant to protease inhibitors are pathogenic in mature human lymphoid tissues

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12 December 2020

Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro

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12 December 2020

Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.

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12 December 2020

Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug

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12 December 2020

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

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12 December 2020

Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance

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12 December 2020

Implications of antiretroviral resistance on viral fitness

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12 December 2020

Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys.

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12 December 2020

Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

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12 December 2020

A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1

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12 December 2020

Rapid phenotypic assay for human immunodeficiency virus type 1 protease using in vitro translation

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12 December 2020

Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients

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12 December 2020

Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults

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12 December 2020

Procedures for reliable estimation of viral fitness from time-series data.

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12 December 2020

Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection

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12 December 2020

Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture

1 reference

12 December 2020

10.1007/S11908-003-0068-9

Identifiers

DOI

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6 August 2017

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