(Q35045012)

6 August 2017

title

Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents (English)

1 reference

6 August 2017

Erika M Becker

1

1 reference

6 August 2017

David B Lovejoy

2

1 reference

6 August 2017

Judith M Greer

3

1 reference

6 August 2017

Ralph Watts

4

1 reference

6 August 2017

Des R Richardson

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 March 2003

1 reference

British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

138

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6 August 2017

issue

5

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6 August 2017

page(s)

819-830

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Constitutive activation of transcription factor AP-2 is associated with decreased MnSOD expression in transformed human lung fibroblasts

6 August 2017

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Failure of iron chelators to reduce tumor growth in human neuroblastoma xenografts

8 July 2018

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The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydra

8 July 2018

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8 July 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

8 July 2018

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The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell

8 July 2018

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8 July 2018

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The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis

8 July 2018

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Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators

8 July 2018

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Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase

8 July 2018

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The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents

8 July 2018

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Inhibition of the growth of cultured cells and an implanted fibrosarcoma by aroylhydrazone analogs of the Gly-His-Lys-Cu(II) complex

8 July 2018

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The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes

8 July 2018

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Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone

8 July 2018

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Effect of desferrioxamine, rhodotorulic acid and cholylhydroxamic acid on transferrin and iron exchange with hepatocytes in culture.

8 July 2018

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Effects of desferrioxamine on normal and leukemic human hematopoietic cell growth: in vitro and in vivo studies.

8 July 2018

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A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.

8 July 2018

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Effects of a single course of deferoxamine in neuroblastoma patients

8 July 2018

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The uptake of iron and transferrin by the human malignant melanoma cell

8 July 2018

1 reference

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Pyridoxal isonicotinoyl hydrazone: an effective iron-chelator after oral administration

8 July 2018

1 reference

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

8 July 2018

1 reference

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A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

8 July 2018

1 reference

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Reduction of Ribonucleotides

8 July 2018

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Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron

8 July 2018

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0705089

Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells

21 January 2018

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Effect of iron chelators on proliferation and iron uptake in hepatoma cells

25 October 2018

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Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy

25 October 2018

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New 8-hydroxyquinoline and catecholate iron chelators: influence of their partition coefficient on their biological activity.

25 October 2018

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Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573713

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573713

Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573713

Tumor cell cytotoxicity of a novel metal chelator.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573713

Role of ribonucleotide reductase in expression in the neoplastic program.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573713

Atomic physicochemical parameters for three-dimensional-structure-directed quantitative structure-activity relationships. 2. Modeling dispersive and hydrophobic interactions

25 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705089

Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant

21 January 2018

1 reference

12 December 2020

Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction

1 reference

12 December 2020

Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture

1 reference

12 December 2020

Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate

1 reference

12 December 2020

Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and an IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity

1 reference

12 December 2020

Deferoxamine, cyclophosphamide, etoposide, carboplatin, and thiotepa (D-CECaT): a new cytoreductive chelation-chemotherapy regimen in patients with advanced neuroblastoma

1 reference

12 December 2020

Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

1 reference

12 December 2020

Deferoxamine in children with recurrent neuroblastoma

1 reference

12 December 2020

Inhibition of lymphoma growth in vivo by combined treatment with hydroxyethyl starch deferoxamine conjugate and IgG monoclonal antibodies against the transferrin receptor

1 reference

12 December 2020

Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neuroblastoma: preliminary results. Italian Neuroblastoma Cooperative Group

1 reference

12 December 2020

Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review)

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12 December 2020

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation

1 reference

12 December 2020

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity

1 reference

12 December 2020

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells

1 reference

12 December 2020

Demonstration of nitrogen coordination in metal-bleomycin complexes by electron spin-echo envelope spectroscopy

1 reference

12 December 2020

Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal

1 reference

12 December 2020

Iron metabolism in K562 erythroleukemic cells

1 reference

12 December 2020

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1 reference

12 December 2020

Antineuroblastoma activity of desferoxamine in human cell lines

1 reference

12 December 2020

Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazone (5-HP; NSC-107392), with special reference to its iron-chelating properties

1 reference

12 December 2020

Studies of the reaction of 2-formylpyridine thiosemicarbazone and its iron and copper complexes with biological systems

1 reference

12 December 2020

Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones

1 reference

12 December 2020

Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent

1 reference

12 December 2020

Deferoxamine inhibition of human neuroblastoma viability and proliferation

1 reference

12 December 2020

Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705089

7 January 2021

inferred from DOI database lookup

Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of ...

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1021/CI00063A006

12 September 2021

Identifiers

DOI

10.1038/SJ.BJP.0705089

1 reference

6 August 2017

1 reference

6 August 2017

1 reference