(Q35057271)

6 August 2017

title

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6. (English)

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6 August 2017

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Carol L Murray

1

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6 August 2017

Donal T Skelly

series ordinal

2

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6 August 2017

Colm Cunningham

series ordinal

3

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6 August 2017

language of work or name

1 reference

17 May 2011

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Journal of Neuroinflammation

6 August 2017

published in

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6 August 2017

volume

8

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6 August 2017

page(s)

50

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https://scigraph.springernature.com/pub.10.1186/1742-2094-8-50

6 August 2017

exact match

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cites work

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Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration

8 July 2018

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The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Minimal penetration of lipopolysaccharide across the murine blood-brain barrier

8 July 2018

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Systemic inflammatory response reactivates immune-mediated lesions in rat brain.

8 July 2018

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Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease

8 July 2018

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Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

8 July 2018

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Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib

8 July 2018

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Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.

8 July 2018

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Systemic infections and inflammation affect chronic neurodegeneration

8 July 2018

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Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease

8 July 2018

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Hypothermia in systemic inflammation: role of cytokines

8 July 2018

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Effect of dexamethasone on elevated cytokine mRNA levels in chemical-induced hippocampal injury

8 July 2018

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Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.

8 July 2018

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Effect of homologous interleukin-1, interleukin-6 and tumor necrosis factor-alpha on the core body temperature of mice

8 July 2018

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Biotinylated lipopolysaccharide binds to endotoxin receptor in endothelial and monocytic cells.

8 July 2018

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Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice

8 July 2018

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Dexamethasone target sites in the central nervous system and their potential relevance to mental illness.

8 July 2018

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Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat.

8 July 2018

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Lipid A-induced tolerance and hyperreactivity to hypothermia in mice

8 July 2018

1 reference

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Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

8 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Peripheral infection and aging interact to impair hippocampal memory consolidation.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Autonomic brainstem nuclei are linked to the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

How does peripheral lipopolysaccharide induce gene expression in the brain of rats?

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Stress increases vulnerability to inflammation in the rat prefrontal cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-50

Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119173

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119173

Absence of detectable IL-1beta production in murine prion disease: a model of chronic neurodegeneration.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119173

Why Dexamethasone Poorly Penetrates in Brain.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119173

Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119173

Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix

25 October 2018

1 reference

12 December 2020

Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice

1 reference

12 December 2020

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

1 reference

12 December 2020

Identifiers

DOI

10.1186/1742-2094-8-50

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference

6 August 2017

1 reference