(Q35057281)

6 August 2017

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title

Toxicokinetic modeling and its applications in chemical risk assessment (English)

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6 August 2017

main subject

chemical risk assessment

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inferred from title

object named as

chemical risk assessment

14 July 2023

Melvin E Andersen

1

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publication date

1 February 2003

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6 August 2017

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6 August 2017

volume

138

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6 August 2017

issue

1-2

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6 August 2017

page(s)

9-27

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Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

6 August 2017

cites work

1 reference

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7 January 2021

Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.

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7 January 2021

Applying simulation modeling to problems in toxicology and risk assessment--a short perspective.

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7 January 2021

Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.

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7 January 2021

Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model.

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7 January 2021

Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: an example with acrylic acid

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7 January 2021

Methotrexate Pharmacokinetics

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7 January 2021

A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity

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7 January 2021

Physiological parameter values for physiologically based pharmacokinetic models

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7 January 2021

Incorporation of biological information in cancer risk assessment: example--vinyl chloride

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7 January 2021

Risk assessment extrapolations and physiological modeling.

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7 January 2021

A physiologically based pharmacokinetic model for retinoic acid and its metabolites

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7 January 2021

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

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7 January 2021

Concentration-dependent disappearance of fluorouracil from peritoneal fluid in the rat: experimental observations and distributed modeling

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7 January 2021

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7 January 2021

Computer simulation in chemical kinetics

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7 January 2021

Cisplatin pharmacokinetics: applications of a physiological model

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7 January 2021

Lifespan oral toxicity study of vinyl chloride in rats

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7 January 2021

Pharmacokinetics of halogenated ethylenes in rats

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7 January 2021

Uptake and Clearance of Inhalation Anesthetics in Man

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7 January 2021

Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways

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7 January 2021

A physiologically based simulation approach for determining metabolic constants from gas uptake data

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7 January 2021

Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes

1 reference

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7 January 2021

Gas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the Rat

1 reference

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7 January 2021

Resolution of dose-response toxicity data for chemicals requiring metabolic activation: Example?Vinyl chloride*1

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7 January 2021

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

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7 January 2021

A review of the applications of physiologically based pharmacokinetic modeling

1 reference

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7 January 2021

A mortality study of vinyl chloride monomer workers employed in the United Kingdom in 1940-1974

1 reference

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7 January 2021

Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species

1 reference

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7 January 2021

A mechanistic model of effects of dioxin on gene expression in the rat liver.

1 reference

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7 January 2021

A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

1 reference

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7 January 2021

Pharmacokinetics of [125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: analysis with a physiological modeling approach

1 reference

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7 January 2021

A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1 reference

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7 January 2021

Development and utilization of physiologically based pharmacokinetic models for toxicological applications

1 reference

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7 January 2021

Pharmacokinetics of Salicylate Elimination in Man

1 reference

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7 January 2021

Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes

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7 January 2021

The kinetics of alcohol elimination in man.

1 reference

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7 January 2021

Carcinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis

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7 January 2021

An electric analogue for uptake and exchange of inert gases and other agents.

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7 January 2021

The pharmacokinetics of inhaled methylene chloride in rats

1 reference

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7 January 2021

Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration

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7 January 2021

The pharmacokinetics of [14C]vinylidene chloride in rats following inhalation exposure

1 reference

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7 January 2021

A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors

1 reference

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7 January 2021

The kinetics of methotrexate polyglutamation in human breast cancer cells

1 reference

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7 January 2021

Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls

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7 January 2021

Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. II. Rates of metabolism

1 reference

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7 January 2021

Physiologically Based Modeling of Vinyl Acetate Uptake, Metabolism, and Intracellular pH Changes in the Rat Nasal Cavity

1 reference

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7 January 2021

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.

1 reference

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7 January 2021

Pharmacokinetics of inhaled styrene in human volunteers.

1 reference

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7 January 2021

Predicting Cancer Risk from Vinyl Chloride Exposure with a Physiologically Based Pharmacokinetic Model

1 reference

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7 January 2021

A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons

1 reference

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7 January 2021

The dose-dependent pharmacokinetic profile of 2,4,5-trichlorophenoxy acetic acid following intravenous administration to rats

1 reference

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7 January 2021

Dose-dependent pharmacokinetic profile of silvex following intravenous administration in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

A collaborative study of cancer incidence and mortality among vinyl chloride workers

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

Distribution and excretion of 2,2′,4,4′,5,5′-hexabromobiphenyl in rats and man: Pharmacokinetic model predictions

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

Fate of [14C]vinyl chloride following inhalation exposure in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

A transcriptional switch mediated by cofactor methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

Dose-dependent fate of 1,4-dioxane in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

Pharmacokinetics of 1,4-dioxane in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4274%2802%2900375-2

7 January 2021

10.1016/S0378-4274(02)00375-2

Identifiers

DOI

1 reference

6 August 2017

1 reference