(Q35062281)

6 August 2017

A role for WRN in telomere-based DNA damage responses (English)

1 reference

6 August 2017

0 references

8

Barbara A Gilchrest

1 reference

6 August 2017

7

Vilhelm A Bohr

1 reference

ORCID Public Data File 2021

6 August 2017

1 reference

author name string

Mark S Eller

1

1 reference

6 August 2017

Xiaodong Liao

2

1 reference

6 August 2017

SuiYang Liu

3

1 reference

6 August 2017

Kendra Hanna

4

1 reference

6 August 2017

Helena Bäckvall

5

1 reference

6 August 2017

Patricia L Opresko

6

1 reference

6 August 2017

language of work or name

English

0 references

publication date

2 October 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

1 reference

6 August 2017

103

1 reference

6 August 2017

15073-15078

1 reference

6 August 2017

41

1 reference

Functional human telomeres are recognized as DNA damage in G2 of the cell cycle

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Human telomeres maintain their overhang length at senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Senescence and immortalization: role of telomeres and telomerase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Telomere-based DNA damage responses: a new approach to melanoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Phosphorylation of H2AX at short telomeres in T cells and fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

A DNA damage checkpoint response in telomere-initiated senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

The serial cultivation of human diploid cell strains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

DNA damage foci at dysfunctional telomeres

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Reversal of human cellular senescence: roles of the p53 and p16 pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3' overhang specific DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Evidence that exposure of the telomere 3' overhang sequence induces senescence

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Induction of apoptosis by telomere 3' overhang-specific DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Senescence Induced by Altered Telomere State, Not Telomere Loss

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Telomere dysfunction: multiple paths to the same end.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Protection of mammalian telomeres

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Stimulation of melanogenesis by DNA oligonucleotides: effect of size, sequence and 5' phosphorylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

The Werner syndrome protein: an update

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Mammalian telomeres end in a large duplex loop

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Nucleolar localization of the Werner syndrome protein in human cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

TRF2 Protects Human Telomeres from End-to-End Fusions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Telomere length regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Kinetics of G-quartet-mediated tetramer formation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Replicative senescence: an old lives' tale?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

A human telomeric protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

In vivostability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

Werner syndrome protein contains three structure-specific DNA binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

The Werner syndrome protein: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

Checkpoints: How to activate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0607332103

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1586178

Erosion of the telomeric single-strand overhang at replicative senescence

27 September 2018

1 reference

12 December 2020

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

12 December 2020

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

12 December 2020

Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrest

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0607332103

1 reference

release_myywllxlsndfbfg4igkycotite

6 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/myywllxlsndfbfg4igkycotite

24 November 2022

mapped directly with Wikidata item

PMCID

1586178

1 reference

6 August 2017

1 reference