(Q52832311)

8 May 2018

title

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. (English)

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8 May 2018

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7

Woodring E Wright

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8 May 2018

Brittney-Shea Herbert

2

object named as

Brittney-Shea Herbert

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8 May 2018

Jerry W Shay

8

object named as

Jerry W Shay

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8 May 2018

author name string

Ruben D Ramirez

1

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8 May 2018

Melville B Vaughan

3

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8 May 2018

Ying Zou

4

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8 May 2018

Kenia Gandia

5

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8 May 2018

Carmela P Morales

6

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8 May 2018

language of work or name

English

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publication date

1 January 2003

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8 May 2018

published in

Oncogene

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8 May 2018

volume

22

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8 May 2018

issue

3

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8 May 2018

page(s)

433-444

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8 May 2018

describes a project that uses

Ker-CT

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exact match

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206046

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cites work

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Increased activity of p53 in senescing fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Identification of CDK4 sequences involved in cyclin D1 and p16 binding

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Telomere loss: mitotic clock or genetic time bomb?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

The telomere hypothesis of cellular aging

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Telomere end-replication problem and cell aging

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

An alternative lifestyle for immortalized oral keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Defining the molecular mechanisms of human cell immortalization

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

The RB and p53 pathways in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Different telomere damage signaling pathways in human and mouse cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Growth of normal human mammary cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206046

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206046

1 reference

8 May 2018

1 reference

8 May 2018