(Q35062441)

6 August 2017

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title

The core-binding factor leukemias: lessons learned from murine models (English)

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6 August 2017

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James R Downing

1

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6 August 2017

1 February 2003

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Current Opinion in Genetics & Development

6 August 2017

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6 August 2017

13

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6 August 2017

1

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6 August 2017

48-54

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The role of the AML1 transcription factor in leukemogenesis

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Core-binding factors in haematopoiesis and leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Causal relationship between the loss of RUNX3 expression and gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Oligomerization of ETO is obligatory for corepressor interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Amplification of AML1 in childhood acute lymphoblastic leukemias

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

AML1 gene over-expression in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

New genes involved in cancer identified by retroviral tagging

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2802%2900018-7

7 January 2021

10.1016/S0959-437X(02)00018-7

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12573435