(Q50335773)

5 March 2018

title

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. (English)

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5 March 2018

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9

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5 March 2018

Pier Paolo Pandolfi

13

object named as

Pier Paolo Pandolfi

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5 March 2018

10

Janet D Rowley

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5 March 2018

Carsten Müller-Tidow

2

object named as

Carsten Müller-Tidow

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5 March 2018

author name string

Bryan Linggi

1

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5 March 2018

Louis van de Locht

3

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5 March 2018

Ming Hu

4

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5 March 2018

John Nip

5

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5 March 2018

Hubert Serve

6

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5 March 2018

Wolfgang E Berdel

7

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5 March 2018

Bert van der Reijden

8

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5 March 2018

John Cleveland

11

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5 March 2018

Joop H Jansen

12

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5 March 2018

Scott W Hiebert

14

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5 March 2018

language of work or name

English

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publication date

24 June 2002

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5 March 2018

published in

Nature Medicine

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5 March 2018

volume

8

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5 March 2018

issue

7

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5 March 2018

page(s)

743-750

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5 March 2018

https://scigraph.springernature.com/pub.10.1038/nm726

exact match

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cites work

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

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7 January 2021

Sequence specificity of the core-binding factor

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7 January 2021

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

7 January 2021

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

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7 January 2021

AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

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7 January 2021

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

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7 January 2021

p14ARF links the tumour suppressors RB and p53.

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7 January 2021

Inhibition of v-Abl transformation by p53 and p19ARF

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7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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7 January 2021

p19ARF links the tumour suppressor p53 to Ras

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7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

1 reference

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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7 January 2021

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7 January 2021

The INK4A/ARF locus and its two gene products

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7 January 2021

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

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7 January 2021

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

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7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

p16ink4a gene and hematological malignancies.

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7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

Expression of p16INK4A and p14ARF in hematological malignancies

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7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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7 January 2021

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

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7 January 2021

p53-independent functions of the p19(ARF) tumor suppressor

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7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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7 January 2021

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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7 January 2021

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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7 January 2021

Identifiers

DOI

10.1038/NM726

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5 March 2018

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5 March 2018