(Q35063686)

6 August 2017

title

Steady-state kinetic mechanism of PDK1. (English)

1 reference

6 August 2017

Xinxin Gao

1

1 reference

6 August 2017

Thomas K Harris

series ordinal

2

1 reference

6 August 2017

language of work or name

English

0 references

publication date

31 May 2006

1 reference

Journal of Biological Chemistry

6 August 2017

published in

1 reference

6 August 2017

volume

281

1 reference

6 August 2017

issue

31

1 reference

6 August 2017

page(s)

21670-21681

1 reference

Coupling phosphoryl transfer and substrate interactions in protein kinases

6 August 2017

cites work

1 reference

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8 July 2018

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PDK1, the master regulator of AGC kinase signal transduction

8 July 2018

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A kinetic approach towards understanding substrate interactions and the catalytic mechanism of the serine/threonine protein kinase ERK2: identifying a potential regulatory role for divalent magnesium

8 July 2018

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Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

8 July 2018

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Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

8 July 2018

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High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

8 July 2018

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Kinetic mechanism for human Rho-Kinase II (ROCK-II).

8 July 2018

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8 July 2018

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

8 July 2018

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

8 July 2018

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Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

8 July 2018

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

8 July 2018

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The PI3K-PDK1 connection: more than just a road to PKB

8 July 2018

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Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

8 July 2018

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90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

8 July 2018

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Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

8 July 2018

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Kinase phosphorylation: Keeping it all in the family

8 July 2018

1 reference

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

8 July 2018

1 reference

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Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

8 July 2018

1 reference

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Intracellular signalling: PDK1--a kinase at the hub of things

8 July 2018

1 reference

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Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

8 July 2018

1 reference

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Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

8 July 2018

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

8 July 2018

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Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

8 July 2018

1 reference

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Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

8 July 2018

1 reference

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

8 July 2018

1 reference

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Phosphorylation and activation of p70s6k by PDK1

8 July 2018

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

8 July 2018

1 reference

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Kinetic mechanism for p38 MAP kinase alpha. A partial rapid-equilibrium random-order ternary-complex mechanism for the phosphorylation of a protein substrate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Proximity-induced catalysis by the protein kinase ERK2.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Computational prediction of protein-protein interactions

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Two Rate-Limiting Steps in the Kinetic Mechanism of the Serine/Threonine Specific Protein Kinase ERK2: A Case of Fast Phosphorylation Followed by Fast Product Release

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Evaluation of the catalytic mechanism of the p21-activated protein kinase PAK2.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1587617

Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16737971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16737971

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M602448200

1 reference

6 August 2017

1 reference

6 August 2017

1 reference