Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q35064994)
Watch
English
Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
title
Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
author
Apolinar Maya-Mendoza
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
author name string
A Ahmed
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
J Yang
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
D A Jackson
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
M Ashcroft
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
publication date
19 May 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
published in
Cell Death and Disease
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
volume
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
page(s)
e160
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
cites work
Hypoxia-inducible factors and the response to hypoxic stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Chk1 promotes replication fork progression by controlling replication initiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
The ATR pathway: fine-tuning the fork
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Chk1 regulates the density of active replication origins during the vertebrate S phase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Novel cancer therapy by reactivation of the p53 apoptosis pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
A p53-dependent checkpoint pathway prevents rereplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Regulation of p53 function and stability by phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
8 July 2018
Activation of a unique p53-dependent DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
27 September 2018
Visualization of altered replication dynamics after DNA damage in human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
27 September 2018
ATM and ATR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122121
retrieved
27 September 2018
Pharmacological rescue of mutant p53 conformation and function
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21593792
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21593792
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/CDDIS.2011.42
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
Fatcat ID
release_mlzsnkg44jgqlm4ifymdp6zuwm
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/mlzsnkg44jgqlm4ifymdp6zuwm
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PMC publication ID
3122121
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed publication ID
21593792
1 reference
stated in
Europe PubMed Central
PMC publication ID
3122121
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593792%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ResearchGate publication ID
51147809
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit