(Q35072420)

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IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling

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Europe PubMed Central

PubMed publication ID

6 August 2017

IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

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author name string

Min Xie

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Anthony T Mustovich

2

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Europe PubMed Central

PubMed publication ID

6 August 2017

Yi Jiang

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

John B Trudeau

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Anuradha Ray

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Prabir Ray

6

1 reference

Europe PubMed Central

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6 August 2017

Haizhen Hu

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Fernando Holguin

8

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Bruce Freeman

9

1 reference

Europe PubMed Central

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6 August 2017

Sally E Wenzel

10

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6 August 2017

language of work or name

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publication date

11 October 2014

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Europe PubMed Central

PubMed publication ID

6 August 2017

The Journal of Allergy and Clinical Immunology

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Europe PubMed Central

PubMed publication ID

6 August 2017

135

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Europe PubMed Central

PubMed publication ID

6 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

386-394

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Respiratory epithelial imbalances in asthma pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Synergy of IL-27 and TNF-α in regulating CXCL10 expression in lung fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

1 reference

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8 July 2018

Asthma phenotypes: the evolution from clinical to molecular approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection

1 reference

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8 July 2018

Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.

1 reference

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8 July 2018

Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-alpha: implications for immunopathophysiology of airway inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

A role for IL-27 in early regulation of Th1 differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

The role of IL-27 in the development of T-cell responses during parasitic infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Expression of IL-27 in human Th1-associated granulomatous diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Mutational switch of an IL-6 response to an interferon-gamma-like response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

Binding of IL-4 to the IL-13Ralpha(1)/IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

8 July 2018

IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Clinical outcome and IL-17, IL-23, IL-27 and FOXP3 expression in peripheral blood mononuclear cells of pollen-allergic children during sublingual immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Production of both IL-27 and IFN-gamma after the treatment with a ligand for invariant NK T cells is responsible for the suppression of Th2 response and allergic inflammation in a mouse experimental asthma model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Alternative activation of STAT1 and STAT3 in response to interferon-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324337

27 September 2018

Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 induces a Th1 immune response and susceptibility to experimental arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-helper 1-related chemokines in the exacerbation of childhood asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38

1 reference

https://pubmed.ncbi.nlm.nih.gov/25312760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JACI.2014.08.023

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

ResearchGate publication ID

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