(Q38007831)

26 August 2017

Asthma phenotypes: the evolution from clinical to molecular approaches (English)

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26 August 2017

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Sally E Wenzel

1

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PubMed ID

22561835

26 August 2017

language of work or name

English

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publication date

4 May 2012

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26 August 2017

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26 August 2017

18

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26 August 2017

716-725

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26 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nm.2678

26 August 2017

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cites work

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T-helper type 2-driven inflammation defines major subphenotypes of asthma.

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Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics

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Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

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Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

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Obesity is a risk factor for dyspnea but not for airflow obstruction

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Effects of steroid therapy on inflammatory cell subtypes in asthma

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The effects of glucocorticoids on human eosinophils

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The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects

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Asthma and increased bronchial responsiveness in elite athletes: atopy and sport event as risk factors

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Concerning the nature of intolerance to aspirin

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A plea to abandon asthma as a disease concept

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Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung/bone marrow axis

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Characterization of within-subject responses to fluticasone and montelukast in childhood asthma

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12 December 2020

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An eosinophil-dependent mechanism for the antitumor effect of interleukin-4

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12 December 2020

A working classification of asthma

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12 December 2020

Asthma: defining of the persistent adult phenotypes

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12 December 2020

Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression

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12 December 2020

Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes

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12 December 2020

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

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12 December 2020

The many paths to asthma: phenotype shaped by innate and adaptive immunity

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12 December 2020

Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D4 receptor antagonist

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12 December 2020

Risk factors associated with symptoms of gastroesophageal reflux

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Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma

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12 December 2020

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice

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12 December 2020

Cluster analysis and clinical asthma phenotypes.

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12 December 2020

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

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12 December 2020

Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry

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12 December 2020

Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma

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12 December 2020

Importance of hedgehog interacting protein and other lung function genes in asthma

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12 December 2020

Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition

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12 December 2020

Long-term studies of the natural history of asthma in childhood

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12 December 2020

A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis

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12 December 2020

Differences in airway cytokine profile in severe asthma compared to moderate asthma.

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12 December 2020

Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma

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Crossref

https://api.crossref.org/works/10.1038%2FNM.2678

7 January 2021

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Glucocorticoids suppress the production of interleukin 4 by human lymphocytes

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12 December 2020

Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist

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12 December 2020

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

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12 December 2020

Childhood eczema and rhinitis predict atopic but not nonatopic adult asthma: A prospective cohort study over 4 decades

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12 December 2020

"Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids

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12 December 2020

Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations

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12 December 2020

Intrinsic asthma: is it intrinsic to the smooth muscle?

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12 December 2020

Urinary Leukotriene E4Concentrations Increase after Aspirin Challenge in Aspirin-sensitive Asthmatic Subjects

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12 December 2020

Obesity and asthma: an association modified by age of asthma onset

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12 December 2020

Inhibition by dexamethasone of human neutrophil apoptosis in vitro

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12 December 2020

IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma

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12 December 2020

Requirement for IL-13 independently of IL-4 in experimental asthma

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12 December 2020

Lebrikizumab treatment in adults with asthma

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12 December 2020

IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist

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12 December 2020

IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells

1 reference

12 December 2020

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

1 reference

12 December 2020

Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia.

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12 December 2020

Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine.

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12 December 2020

The ABCs of rhinoviruses, wheezing, and asthma

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12 December 2020

Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation

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12 December 2020

Mepolizumab and exacerbations of refractory eosinophilic asthma

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12 December 2020

Interleukin-13: central mediator of allergic asthma

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12 December 2020

Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial

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12 December 2020

A comparison of obese and nonobese people with asthma: exploring an asthma-obesity interaction.

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12 December 2020

Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

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12 December 2020

Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients.

1 reference

12 December 2020

A large-scale, consortium-based genomewide association study of asthma

1 reference

12 December 2020

Nitric oxide in exhaled air is a new marker of airway inflammation.

1 reference

12 December 2020

Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.

1 reference

12 December 2020

Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma

1 reference

12 December 2020

The CXCL10/CXCR3 Axis Mediates Human Lung Mast Cell Migration to Asthmatic Airway Smooth Muscle

1 reference

12 December 2020

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

1 reference

12 December 2020

Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma

1 reference

12 December 2020

Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of dexamethasone

1 reference

12 December 2020

An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications

1 reference

12 December 2020

Qualitative analysis of high-resolution CT scans in severe asthma

1 reference

12 December 2020

Influence of body mass index on the response to asthma controller agents

1 reference

12 December 2020

Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation.

1 reference

12 December 2020

Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma

1 reference

12 December 2020

Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution

1 reference

12 December 2020

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

1 reference

12 December 2020

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

1 reference

12 December 2020

Neutrophilic inflammation in severe persistent asthma

1 reference

12 December 2020

Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial.

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12 December 2020

Is allergen exposure the major primary cause of asthma?

1 reference

12 December 2020

Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics

1 reference

12 December 2020

The role of female sex hormones in the development and severity of allergic and non-allergic asthma

1 reference

12 December 2020

Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide

1 reference

12 December 2020

Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma

1 reference

12 December 2020

The effects of bariatric surgery on asthma severity.

1 reference

12 December 2020

Induced sputum cell counts in healthy adults

1 reference

12 December 2020

Leptin regulates proinflammatory immune responses

1 reference

12 December 2020

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

1 reference

12 December 2020

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease

1 reference

12 December 2020

Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma

1 reference

12 December 2020

Does obesity produce a distinct asthma phenotype?

1 reference

12 December 2020

Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome

1 reference

12 December 2020

High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma

1 reference

12 December 2020

Prednisone-dependent asthma: inflammatory indices in induced sputum

1 reference

12 December 2020

An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils

1 reference

12 December 2020

Inflammatory basis of exercise-induced bronchoconstriction

1 reference

12 December 2020

Add-on omalizumab improves day-to-day symptoms in inadequately controlled severe persistent allergic asthma

1 reference

12 December 2020

Mechanisms of occupational asthma

1 reference

12 December 2020

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

1 reference

12 December 2020

Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children

1 reference

12 December 2020

A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma

1 reference

12 December 2020

Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma

1 reference

12 December 2020

Identifying adult asthma phenotypes using a clustering approach

1 reference

12 December 2020

Asthma in smokers: challenges and opportunities

1 reference

12 December 2020

The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics

1 reference

12 December 2020

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

1 reference

12 December 2020

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

1 reference

12 December 2020

T lymphocytes that infiltrate nasal polyps have a specialized phenotype and produce a mixed TH1/TH2 pattern of cytokines.

1 reference

12 December 2020

Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.

1 reference

12 December 2020

Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.

1 reference

12 December 2020

The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation

1 reference

12 December 2020

Obesity and estrogen as risk factors for gastroesophageal reflux symptoms

1 reference

12 December 2020

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation

1 reference

12 December 2020

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

1 reference

12 December 2020

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.

1 reference

12 December 2020

TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

1 reference

12 December 2020

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

1 reference

12 December 2020

Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study

1 reference

12 December 2020

Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13.

1 reference

12 December 2020

Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma.

1 reference

12 December 2020

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity

1 reference

12 December 2020

Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program

1 reference

12 December 2020

A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation

1 reference

12 December 2020

A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population.

1 reference

12 December 2020

Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma

1 reference

12 December 2020

Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation

1 reference

12 December 2020

Clarithromycin targets neutrophilic airway inflammation in refractory asthma.

1 reference

12 December 2020

Airway immunopathology of asthma with exercise-induced bronchoconstriction

1 reference

12 December 2020

Eosinophil apoptosis and the resolution of airway inflammation in asthma

1 reference

12 December 2020

IL-5 synthesis is upregulated in human nasal polyp tissue

1 reference

12 December 2020

Induced sputum cellularity. Reference values and distribution in normal volunteers

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.2678

1 reference

26 August 2017

1 reference

PubMed ID

22561835