(Q35074117)

6 August 2017

title

Small molecule screening in human induced pluripotent stem cell-derived terminal cell types (English)

1 reference

Human Induced Pluripotent Stem Cells

6 August 2017

main subject

1 reference

Sandra J Engle

1

1 reference

6 August 2017

Fabien Vincent

series ordinal

2

1 reference

6 August 2017

language of work or name

English

0 references

publication date

20 December 2013

1 reference

6 August 2017

number of pages

9

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

6 August 2017

volume

289

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6 August 2017

issue

8

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6 August 2017

page(s)

4562-4570

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Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling

6 August 2017

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.

8 July 2018

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8 July 2018

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Identification of small molecules for human hepatocyte expansion and iPS differentiation

8 July 2018

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High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.

8 July 2018

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Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells

8 July 2018

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Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells

8 July 2018

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A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

8 July 2018

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Automated selection and harvesting of pluripotent stem cell colonies

8 July 2018

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Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors

8 July 2018

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Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling

8 July 2018

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Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity

8 July 2018

1 reference

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The why and how of phenotypic small-molecule screens

8 July 2018

1 reference

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Genomic responses in mouse models poorly mimic human inflammatory diseases

8 July 2018

1 reference

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Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells

8 July 2018

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Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

8 July 2018

1 reference

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Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen

8 July 2018

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Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events.

8 July 2018

1 reference

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Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Adapting human pluripotent stem cells to high-throughput and high-content screening

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

8 July 2018

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Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects

8 July 2018

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Establishment of a molecular embryonic stem cell developmental toxicity assay

8 July 2018

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A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation.

8 July 2018

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Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells

8 July 2018

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A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

8 July 2018

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Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

8 July 2018

1 reference

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Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells

8 July 2018

1 reference

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Generation of induced pluripotent stem cells from a small amount of human peripheral blood using a combination of activated T cells and Sendai virus

8 July 2018

1 reference

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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

8 July 2018

1 reference

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Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression

8 July 2018

1 reference

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Diagnosing the decline in pharmaceutical R&D efficiency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Overcoming reprogramming resistance of Fanconi anemia cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

8 July 2018

1 reference

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Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome

8 July 2018

1 reference

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Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

8 July 2018

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

8 July 2018

1 reference

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Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation.

8 July 2018

1 reference

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Human pluripotent stem cells: the development of high-content screening strategies.

8 July 2018

1 reference

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Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

8 July 2018

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The business of exploiting induced pluripotent stem cells

8 July 2018

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How were new medicines discovered?

8 July 2018

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Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes

8 July 2018

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A screen for regulators of survival of motor neuron protein levels

8 July 2018

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Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

8 July 2018

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Modelling schizophrenia using human induced pluripotent stem cells

8 July 2018

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Endothelial cells from embryonic stem cells in a chemically defined medium

8 July 2018

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Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

8 July 2018

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Cell death assays for drug discovery

8 July 2018

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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

8 July 2018

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Primary cells and stem cells in drug discovery: emerging tools for high-throughput screening

8 July 2018

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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

8 July 2018

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

8 July 2018

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High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

8 July 2018

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Epigenetic memory in induced pluripotent stem cells

8 July 2018

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Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes

8 July 2018

1 reference

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Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies

8 July 2018

1 reference

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E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Can animal models of disease reliably inform human studies?

8 July 2018

1 reference

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High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

8 July 2018

1 reference

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Induced pluripotent stem cells from a spinal muscular atrophy patient

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Guidelines and techniques for the generation of induced pluripotent stem cells

8 July 2018

1 reference

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

8 July 2018

1 reference

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Induced pluripotent stem cell lines derived from human somatic cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Bringing primary cells to mainstream drug development and drug testing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Classical vs reverse pharmacology in drug discovery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Endothelial progenitor cells from human dental pulp-derived iPS cells as a therapeutic target for ischemic vascular diseases.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Modeling human disease with pluripotent stem cells: from genome association to function.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Highly efficient directed differentiation of human induced pluripotent stem cells into cardiomyocytes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Using human pluripotent stem cell-derived dopaminergic neurons to evaluate candidate Parkinson's disease therapeutic agents in MPP+ and rotenone models.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Improved method of producing human neural progenitor cells of high purity and in large quantities from pluripotent stem cells for transplantation studies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Evaluation of hepatotoxicity of chemicals using hepatic progenitor and hepatocyte-like cells derived from mouse embryonic stem cells: effect of chemicals on ESC-derived hepatocyte differentiation.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Trial watch: Phase II failures: 2008-2010.

27 September 2018

1 reference

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Impact of high-throughput screening in biomedical research

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

What's wrong with drug screening today

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3931017

Classical vs reverse pharmacology in drug discovery

27 September 2018

1 reference

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Broader Implications of Defining Standards for the Pluripotency of iPSCs

21 January 2018

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Scalable expansion of human pluripotent stem cells in suspension culture

21 January 2018

1 reference

12 December 2020

A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions

1 reference

12 December 2020

Alternative induced pluripotent stem cell characterization criteria for in vitro applications

1 reference

12 December 2020

Cell-based assays for high-throughput screening

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.R113.529156

1 reference

6 August 2017

1 reference

6 August 2017

1 reference