(Q35077278)

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Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

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1 November 2019

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Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics (English)

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1 November 2019

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Elisabeth P Carpenter

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1 November 2019

Michael H. Gelb

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Michael H Gelb

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1 November 2019

Frederick S Buckner

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1 November 2019

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Kohei Yokoyama

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1 November 2019

Richard T Eastman

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1 November 2019

Wesley C Van Voorhis

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Wesley C Van Voorhis

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1 November 2019

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Chrysoula Panethymitaki

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1 November 2019

Katherine A Brown

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1 November 2019

Deborah F Smith

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1 November 2019

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1 February 2003

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1 November 2019

Molecular and Biochemical Parasitology

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1 November 2019

126

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1 November 2019

2

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1 November 2019

155-163

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1 November 2019

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein prenyltransferases.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Prenylation of proteins in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein prenyl transferase activities of Plasmodium falciparum

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Current status of clinical trials of farnesyltransferase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

GTPases in protozoan parasites: tools for cell biology and chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi: cloning, trans-splicing, and prenylation studies

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Geranylgeranylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic and biochemical studies of protein N-myristoylation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The biology and enzymology of protein N-myristoylation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of myristoyl-CoA:protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the anti-fungal target N-myristoyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A second mammalian N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifung

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Myristic acid analogs are inhibitors of Junin virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

An analog of myristic acid with selective toxicity for African trypanosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Toxicity of myristic acid analogs toward African trypanosomes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a hydrophilic surface protein in infective stages of Leishmania major

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterisation of a second protein encoded by the differentially regulated LmcDNA16 gene family of Leishmania major

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Acylation-dependent Protein Export in Leishmania

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of N-myristoyltransferase from Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative protein modelling by satisfaction of spatial restraints

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0166-6851(02)00282-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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