(Q35084273)

6 August 2017

title

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells (English)

1 reference

6 August 2017

10

T Fojo

1 reference

6 August 2017

P Giannakakou

1

1 reference

6 August 2017

R Gussio

2

1 reference

6 August 2017

E Nogales

3

1 reference

6 August 2017

K H Downing

4

1 reference

6 August 2017

D Zaharevitz

5

1 reference

6 August 2017

B Bollbuck

6

1 reference

6 August 2017

G Poy

7

1 reference

6 August 2017

D Sackett

8

1 reference

6 August 2017

K C Nicolaou

9

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 March 2000

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

97

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6 August 2017

issue

6

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6 August 2017

page(s)

2904-2909

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Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

A common pharmacophore for cytotoxic natural products that stabilize microtubules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

High-resolution model of the microtubule

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Structure of the alpha beta tubulin dimer by electron crystallography

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Synthesis of epothilones A and B in solid and solution phase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Taxol: the chemistry and structure-activity relationships of a novel anticancer agent

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16028

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.040546297

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.040546297

Total Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.040546297

Cancer drugs better than taxol?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.040546297

Tumor-killer made; how does it work?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.040546297

Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.040546297

Conformational changes of small molecules binding to proteins

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10688884

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.040546297

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference