(Q35091123)

6 August 2017

1 reference

title

The role of the Bcl-2 protein family in cancer (English)

1 reference

6 August 2017

1 reference

Andreas Strasser

2

0 references

author name string

Leigh Coultas

series ordinal

1

1 reference

6 August 2017

1 April 2003

1 reference

Seminars in Cancer Biology

6 August 2017

1 reference

6 August 2017

13

1 reference

6 August 2017

115-123

1 reference

6 August 2017

2

1 reference

The molecular biology of apoptosis

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

1 reference

7 January 2021

The biochemistry of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Programmed cell death in animal development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Cell death control in lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Death receptors: signaling and modulation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Corpse clearance defines the meaning of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The role of ARK in stress-induced apoptosis in Drosophila cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

1 reference

7 January 2021

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

bcl2 and v-abl oncogenes cooperate to immortalize murine B cells that secrete antigen specific antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

A matter of life and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Genetic analysis of chemoresistance in primary murine lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900129-3

7 January 2021

10.1016/S1044-579X(02)00129-3

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12654255