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Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
title
Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
author
Sunil C Kaul
series ordinal
3
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
Feng Lan
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4
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
Renu Wadhwa
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6
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PMC publication ID
3131943
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
John M. Luk
series ordinal
7
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PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
author name string
W-J Lu
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
N P Lee
series ordinal
2
1 reference
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
R T P Poon
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5
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
publication date
14 January 2011
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Europe PubMed Central
PMC publication ID
3131943
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
published in
Cell Death & Differentiation
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Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
volume
18
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
page(s)
1046-1056
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/cdd.2010.177
0 references
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Small heat shock protein alphaB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis
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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
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Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers
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Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
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Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values
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Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.
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Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
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Intrinsic tumour suppression
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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
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Sequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis
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Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
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An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?
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9 July 2018
ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified
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Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell
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9 July 2018
Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus
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Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line
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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
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9 July 2018
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
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9 July 2018
Interaction between hsp70 and hsp40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant-type p53.
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21 January 2018
Mortalin controls centrosome duplication via modulating centrosomal localization of p53.
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21 January 2018
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
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27 September 2018
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival
1 reference
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PubMed
reference URL
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/CDD.2010.177
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
PMC publication ID
3131943
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
PubMed publication ID
21233847
1 reference
stated in
Europe PubMed Central
PMC publication ID
3131943
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21233847%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 January 2020
ResearchGate publication ID
49754337
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