(Q40252256)

18 September 2017

title

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation (English)

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18 September 2017

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Andrei V Gudkov

12

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author name string

Evguenia Strom

1

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18 September 2017

Swati Sathe

2

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18 September 2017

Pavel G Komarov

3

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18 September 2017

Olga B Chernova

4

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18 September 2017

Ivanda Pavlovska

5

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18 September 2017

Inna Shyshynova

6

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18 September 2017

Dmitry A Bosykh

7

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18 September 2017

Lyudmila G Burdelya

8

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18 September 2017

Roger M Macklis

9

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18 September 2017

Rami Skaliter

10

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18 September 2017

Elena A Komarova

11

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18 September 2017

publication date

23 July 2006

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18 September 2017

published in

Nature Chemical Biology

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18 September 2017

volume

2

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18 September 2017

issue

9

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18 September 2017

page(s)

474-479

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https://scigraph.springernature.com/pub.10.1038/nchembio809

18 September 2017

exact match

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cites work

Could p53 be a target for therapeutic suppression?

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO809

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

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Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors

21 January 2018

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The role of p53 in determining sensitivity to radiotherapy

21 January 2018

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Prospective therapeutic applications of p53 inhibitors

21 January 2018

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

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p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

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Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO809

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO809

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO809

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

21 January 2018

1 reference

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Stress-induced p53 runs a transcription-independent death program

21 January 2018

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Assessing TP53 status in human tumours to evaluate clinical outcome

21 January 2018

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21 January 2018

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Twenty years of p53 research: structural and functional aspects of the p53 protein

21 January 2018

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The promise and obstacle of p53 as a cancer therapeutic agent

21 January 2018

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Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction

21 January 2018

1 reference

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Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

21 January 2018

1 reference

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Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

21 January 2018

1 reference

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

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p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

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Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

21 January 2018

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Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment

21 January 2018

1 reference

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Radiation-induced apoptosis in the adult central nervous system is p53-dependent

21 January 2018

1 reference

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7 January 2021

inferred from DOI database lookup

Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO809

7 January 2021

inferred from DOI database lookup

p53 is a suppressor of inflammatory response in mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO809

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO809

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Dimensions Publication ID

18 September 2017

1014377287

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Fatcat ID

release_u2hbvzlmfre4jiys7w4re3ola4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u2hbvzlmfre4jiys7w4re3ola4

24 November 2022

mapped directly with Wikidata item

1 reference