(Q35094786)

6 August 2017

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title

Parkin's substrates and the pathways leading to neuronal damage (English)

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6 August 2017

1

Mark R Cookson

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6 August 2017

publication date

1 January 2003

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6 August 2017

published in

NeuroMolecular Medicine

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6 August 2017

volume

3

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6 August 2017

issue

1

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6 August 2017

page(s)

1-13

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

6 August 2017

cites work

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12 December 2020

Visualization of prosomes (MCP-proteasomes), intermediate filament and actin networks by "instantaneous fixation" preserving the cytoskeleton

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12 December 2020

Parkin expression in the adult mouse brain

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12 December 2020

U box proteins as a new family of ubiquitin-protein ligases

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12 December 2020

Ubiquitin and its kin: how close are the family ties?

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12 December 2020

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12 December 2020

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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12 December 2020

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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12 December 2020

A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest

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12 December 2020

Structure and functions of the 20S and 26S proteasomes

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12 December 2020

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

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12 December 2020

Synphilin-1 is present in Lewy bodies in Parkinson's disease

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12 December 2020

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

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12 December 2020

Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease.

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12 December 2020

Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: detailed genetic mapping of the linked region

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12 December 2020

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12 December 2020

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.

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12 December 2020

Lewy bodies and parkinsonism in families with parkin mutations

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12 December 2020

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

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12 December 2020

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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12 December 2020

Proteasomal function is impaired in substantia nigra in Parkinson's disease

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12 December 2020

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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12 December 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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12 December 2020

Complex relationship between Parkin mutations and Parkinson disease

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12 December 2020

Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene

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12 December 2020

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12 December 2020

Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease

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12 December 2020

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

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12 December 2020

Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease

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12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

Ubiquitin-dependent protein degradation

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12 December 2020

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

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12 December 2020

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

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12 December 2020

E3 ubiquitin-protein ligase activity of Parkin is dependent on cooperative interaction of RING finger (TRIAD) elements

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12 December 2020

Co-association of parkin and alpha-synuclein

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12 December 2020

Significant association between the tau gene A0/A0 genotype and Parkinson's disease.

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12 December 2020

Cloning and distribution of the rat parkin mRNA.

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12 December 2020

Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations.

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12 December 2020

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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12 December 2020

Parkin is associated with cellular vesicles

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12 December 2020

The Tau H1 Haplotype is associated with Parkinson's disease in the Norwegian population

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12 December 2020

Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease

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12 December 2020

Cloning of rat parkin cDNA and distribution of parkin in rat brain

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12 December 2020

Evolution and function of ubiquitin-like protein-conjugation systems

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12 December 2020

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

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12 December 2020

Genetics of Parkinsonism: a review

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12 December 2020

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12 December 2020

The cell biology of alpha-synuclein: a sticky problem?

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12 December 2020

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12 December 2020

Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: expanding the phenotype.

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12 December 2020

The ubiquitin pathway in Parkinson's disease

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12 December 2020

Parkin is associated with actin filaments in neuronal and nonneural cells

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12 December 2020

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

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12 December 2020

New insights into genetic and molecular mechanisms of brain degeneration in tauopathies

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12 December 2020

Association between early-onset Parkinson's disease and mutations in the parkin gene

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12 December 2020

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

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12 December 2020

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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12 December 2020

Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms

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12 December 2020

Cell biology. Ubiquitin lives up to its name

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12 December 2020

[Early-onset parkinsonism with diurnal fluctuation--clinical and pathological studies]

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12 December 2020

Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells

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12 December 2020

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

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12 December 2020

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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12 December 2020

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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12 December 2020

Apoptotic and anti-apoptotic synaptic signaling mechanisms

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12 December 2020

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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12 December 2020

Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies

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12 December 2020

Ubiquitination-dependent mechanisms regulate synaptic growth and function.

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12 December 2020

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

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12 December 2020

Identifiers

DOI

10.1385/NMM:3:1:1

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Dimensions Publication ID

6 August 2017

1026987323

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