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Therapeutic potential of phosphoinositide 3-kinase inhibitors.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Therapeutic potential of phosphoinositide 3-kinase inhibitors
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
author
Stephen G Ward
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
James Dowden
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
author name string
Yannis Sotsios
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
Ian Bruce
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
Peter Finan
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
publication date
1 March 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
published in
Chemistry and Biology
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
volume
10
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
page(s)
207-213
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
cites work
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The phosphoinositide 3-kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and function of 3-phosphorylated inositol lipids
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PI 3-kinase: a pivotal pathway in T-cell activation?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATP site-directed competitive and irreversible inhibitors of protein kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specificity and mechanism of action of some commonly used protein kinase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppressor PTEN mediates sensing of chemoattractant gradients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance to thromboembolism in PI3Kgamma-deficient mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphatidylinositol 3-kinase: a key regulator of vascular tone?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PIK3CA is implicated as an oncogene in ovarian cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PIK3CA as an oncogene in cervical cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PTEN: life as a tumor suppressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AKT plays a central role in tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of chemokine receptors in breast cancer metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt/protein kinase B promotes organ growth in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900048-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1074-5521(03)00048-6
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
PubMed ID
12670534
1 reference
stated in
Europe PubMed Central
PubMed ID
12670534
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12670534%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 November 2019
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