(Q35096900)

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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602576%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602576%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Giardia lamblia

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Michael Duchene

6

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1 February 2020

Jacqueline A. Upcroft

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Jacqueline A Upcroft

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1 February 2020

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Peter Upcroft

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1 February 2020

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David Leitsch

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1 February 2020

Anita G Burgess

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1 February 2020

Linda A Dunn

3

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1 February 2020

Kenia G Krauer

4

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1 February 2020

Kevin Tan

5

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1 February 2020

Lars Eckmann

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1 February 2020

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22 May 2011

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1 February 2020

Journal of Antimicrobial Chemotherapy

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1 February 2020

66

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1 February 2020

8

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1 February 2020

1756-1765

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1 February 2020

A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities

1 reference

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9 July 2018

A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole

1 reference

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9 July 2018

The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia

1 reference

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9 July 2018

Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Pathophysiology of enteric infections with Giardia duodenalius

1 reference

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9 July 2018

The O2-scavenging flavodiiron protein in the human parasite Giardia intestinalis

1 reference

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9 July 2018

Riboflavin biosynthesis is associated with assimilatory ferric reduction and iron acquisition by Campylobacter jejuni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Measurement of action spectra of light-activated processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Alternative pathway of metronidazole activation in Trichomonas vaginalis hydrogenosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Entamoeba histolytica: analysis of the trophozoite proteome by two-dimensional polyacrylamide gel electrophoresis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

New findings in beta-lactam and metronidazole resistant Bacteroides fragilis group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Mechanism and clinical significance of metronidazole resistance in Helicobacter pylori.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Drug targets and mechanisms of resistance in the anaerobic protozoa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Evaluation of Secnidazole Gel and Tinidazole Suspension in the Treatment of Giardiasis in Children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Physiological functions of thioredoxin and thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Inhibition of pyruvate-ferredoxin oxidoreductase gene expression in Giardia lamblia by a virus-mediated hammerhead ribozyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Antibiotic resistance mechanisms of Helicobacter pylori

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Helicobacter pylori ribBA-mediated riboflavin production is involved in iron acquisition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Metabolism of a 5-nitroimidazole in susceptible and resistant isogenic strains of Bacteroides fragilis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

A thioredoxin reductase-class of disulphide reductase in the protozoan parasite Giardia duodenalis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

P-glycoproteins and multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Nitroimidazole drugs-action and resistance mechanisms I. Mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

The purification and properties of two soluble reduced nicotinamide: acceptor oxidoreductases from Trichomonas vaginalis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Possible roles for pyruvate:ferredoxin oxidoreductase and thiol-dependent peroxidase and reductase activities in resistance to nitroheterocyclic drugs in Giardia intestinalis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Altered uptake of metronidazole in vitro by stocks of Giardia intestinalis with different drug sensitivities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

The in-vitro activity of drugs against Blastocystis hominis

1 reference

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9 July 2018

Induction of metronidazole and furazolidone resistance in Giardia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

9 July 2018

Giardia lamblia encodes a functional flavohemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

27 September 2018

Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

27 September 2018

Hydrogenosomes of laboratory-induced metronidazole-resistant Trichomonas vaginalis lines are downsized while those from clinically metronidazole-resistant isolates are not.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3133484

27 September 2018

Overexpression of the rhamnose catabolism regulatory protein, RhaR: a novel mechanism for metronidazole resistance in Bacteroides thetaiotaomicron.

1 reference

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27 September 2018

In vitro resistance to 5-nitroimidazoles and benzimidazoles in Giardia duodenalis: variability and variation in gene expression.

1 reference

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27 September 2018

Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity

1 reference

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27 September 2018

Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole.

1 reference

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27 September 2018

5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis

1 reference

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27 September 2018

A likely molecular basis of the susceptibility of Giardia lamblia towards oxygen

1 reference

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27 September 2018

Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract

1 reference

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27 September 2018

Oxygen affinities of metronidazole-resistant and -sensitive stocks of Giardia intestinalis.

1 reference

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27 September 2018

Metronidazole resistant Trichomonas vaginalis in Brisbane.

1 reference

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27 September 2018

A purified ferredoxin from Giardia duodenalis

1 reference

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27 September 2018

Mode of action of metronidazole on anaerobic bacteria and protozoa

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anaerobic reduction of nitroimidazoles by reduced flavin mononucleotide and by xanthine oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ferredoxin involvement in metronidazole resistance of Giardia duodenalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A H2O-producing NADH oxidase from the protozoan parasite Giardia duodenalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogenosomal ferredoxin of the anaerobic protozoon, Tritrichomonas foetus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug resistance in Giardia: clinical versus laboratory isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21602576

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/JAC/DKR192

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602576%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602576%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602576%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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