(Q35098725)

English

Structure based design, synthesis, pharmacophore modeling, virtual screening, and molecular docking studies for identification of novel cyclophilin D inhibitors

scientific article

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

Structure based design, synthesis, pharmacophore modeling, virtual screening, and molecular docking studies for identification of novel cyclophilin D inhibitors (English)

1 reference

Europe PubMed Central

6 August 2017

molecular design

0 references

virtual screening

1 reference

based on heuristic

inferred from title

author name string

Koteswara Rao Valasani

1

1 reference

Europe PubMed Central

6 August 2017

Jhansi Rani Vangavaragu

2

1 reference

Europe PubMed Central

6 August 2017

Victor W Day

3

1 reference

Europe PubMed Central

6 August 2017

Shirley ShiDu Yan

4

1 reference

Europe PubMed Central

6 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

28 February 2014

1 reference

Europe PubMed Central

6 August 2017

Journal of Chemical Information and Modeling

1 reference

Europe PubMed Central

6 August 2017

54

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Europe PubMed Central

6 August 2017

3

1 reference

Europe PubMed Central

6 August 2017

902-912

1 reference

Europe PubMed Central

6 August 2017

Identification of human ABAD inhibitors for rescuing Aβ-mediated mitochondrial dysfunction

1 reference

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9 July 2018

Structure-based design and synthesis of benzothiazole phosphonate analogues with inhibitors of human ABAD-Aβ for treatment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

γ-secretase inhibitors prevent overgrowth of transplanted neural progenitors derived from human-induced pluripotent stem cells

1 reference

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9 July 2018

New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain

1 reference

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9 July 2018

Structure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal Structure

1 reference

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9 July 2018

Disease modifying drugs targeting β-amyloid

1 reference

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9 July 2018

Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood

1 reference

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9 July 2018

A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization

1 reference

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9 July 2018

Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization

1 reference

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9 July 2018

Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore

1 reference

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9 July 2018

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein

1 reference

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9 July 2018

Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Towards disease-modifying treatment of Alzheimer's disease: drugs targeting beta-amyloid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Molecules that target beta-amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Peptidylproline cis/trans isomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

9 July 2018

Acetylcholinesterase inhibitors: structure based design, synthesis, pharmacophore modeling, and virtual screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Novel cyclophilin D inhibitors derived from quinoxaline exhibit highly inhibitory activity against rat mitochondrial swelling and Ca2+ uptake/ release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors.

1 reference

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27 September 2018

Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985759

27 September 2018

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca2+ and Oxidant Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and peptidyl-prolyl isomerase inhibitory activity of quinoxalines as ligands of cyclophilin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

QSAR model for alignment-free prediction of human breast cancer biomarkers based on electrostatic potentials of protein pseudofolding HP-lattice networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24555519

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/CI5000196

1 reference

Europe PubMed Central

6 August 2017

DBLP publication ID

journals/jcisd/ValasaniVDY14

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

6 August 2017

ResearchGate publication ID

0 references

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