(Q35104982)

English

The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine

scientific article published on March 1, 2003

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scholarly article

1 reference

Europe PubMed Central

6 August 2017

1 reference

Europe PubMed Central

The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine (English)

1 reference

Europe PubMed Central

6 August 2017

1

object named as

Hermann M Bolt

1 reference

Europe PubMed Central

6 August 2017

author name string

Ricarda Thier

3

1 reference

Europe PubMed Central

6 August 2017

Hermann M. Bolt

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690492

23 December 2023

Peter H. Roos

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690492

23 December 2023

language of work or name

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12690492

23 December 2023

publication date

1 March 2003

1 reference

Europe PubMed Central

6 August 2017

International Archives of Occupational and Environmental Health

1 reference

Europe PubMed Central

6 August 2017

76

1 reference

Europe PubMed Central

6 August 2017

3

1 reference

Europe PubMed Central

6 August 2017

174-185

1 reference

Europe PubMed Central

6 August 2017

https://scigraph.springernature.com/pub.10.1007/s00420-002-0407-4

0 references

Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection and characterization of novel polymorphisms in the CYP2E1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol-xenobiotic interactions. Role of cytochrome P450 2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chapter 14. Ah receptor gene polymorphisms and human cancer susceptibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental pharmacokinetics and toxicology of acrylonitrile

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism]

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Occupational exposures to mists and vapours from strong inorganic acids and other industrial chemicals. Working Group views and expert opinions, Lyon, 15-22 October 1991

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of normal aging on the activity of human hepatic cytochrome P450IIE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The new era of toxicology

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of glutathione transferase theta polymorphism on the risk estimates of dichloromethane to humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological monitoring of n-hexane exposure in Portuguese shoe manufacturing workers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acrylonitrile (vinyl cyanide) poisoning: a case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the acute acrylonitrile-induced neurotoxicity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal toxicity of acrylonitrile: in vitro metabolism by intestinal cytochrome P450 2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal metabolism of acrylonitrile to cyanide: in vitro studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of N-nitrosodialkylamines by human liver microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2E1 expression in human lymphocytes from various ethnic populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization, sequence analysis, and ethnic distribution of a 96-bp insertion in the promoter of the human CYP2E1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the development of new toxicological concepts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism of cytochrome P-450 in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interindividual differences in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase in 22 human liver samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphism of human CYP2E1: characterization of two variant alleles

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary 2,5 hexanedione as a biomarker of n-hexane exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CYP2E1 in human lung and kidney during development and in full-term placenta: a differential methylation of the gene is involved in the regulation process.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic gene polymorphism frequencies in control populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genetic polymorphism in the regulatory sequences of human CYP2E1: association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression and methylation of the human CYP2E1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in acrylonitrile metabolism and toxicity between experimental animals and humans based on observations in human accidental poisonings

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/12690492

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IARC scientific publications

21

148

149

author name string

Garte

publication date

1999

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

Molecular Pharmacology

31

51

370

author name string

Hu

publication date

1997

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

38

30

63

author name string

Iwahashi

publication date

1995

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

Alcoholism: Clinical and Experimental Research

51

23

991

author name string

Lieber

publication date

1999

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

The P450 gene superfamily: recommended nomenclature.

62

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

Giornale italiano di medicina del lavoro

68

6

77

author name string

Peter

publication date

1984

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression

89

1 reference

10.1007/S00420-002-0407-4

https://api.crossref.org/works/10.1007/S00420-002-0407-4

23 December 2023

Identifiers

10.1007/S00420-002-0407-4

0 references

1 reference

Europe PubMed Central

6 August 2017

ResearchGate publication ID

0 references

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