(Q35106787)

6 August 2017

title

Reengineering rate-limiting, millisecond enzyme motions by introduction of an unnatural amino acid (English)

1 reference

6 August 2017

Eric D Watt

1

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Ivan Rivalta

object named as

Ivan Rivalta

2

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author name string

Sean K Whittier

3

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6 August 2017

Victor S Batista

4

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6 August 2017

J Patrick Loria

5

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6 August 2017

language of work or name

English

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publication date

1 July 2011

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6 August 2017

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6 August 2017

volume

101

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6 August 2017

issue

2

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6 August 2017

page(s)

411-420

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Investigation of an unnatural amino acid for use as a resonance Raman probe: Detection limits, solvent and temperature dependence of the νC≡N band of 4-cyanophenylalanine

6 August 2017

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9 July 2018

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Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulations

9 July 2018

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9 July 2018

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The flexibility of a distant loop modulates active site motion and product release in ribonuclease A.

9 July 2018

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9 July 2018

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Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

9 July 2018

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Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity

9 July 2018

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In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy

9 July 2018

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The mechanism of rate-limiting motions in enzyme function.

9 July 2018

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An inserted Gly residue fine tunes dynamics between mesophilic and thermophilic ribonucleases H

9 July 2018

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9 July 2018

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9 July 2018

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Conservation of mus-ms enzyme motions in the apo- and substrate-mimicked state

9 July 2018

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Molecular dynamics and protein function

9 July 2018

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9 July 2018

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9 July 2018

Tissue sulfhydryl groups

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Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules

9 July 2018

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Computer-based redesign of a protein folding pathway

9 July 2018

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Hypersensitive substrate for ribonucleases

9 July 2018

1 reference

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Side-chain and backbone flexibility in protein core design

9 July 2018

1 reference

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High-resolution protein design with backbone freedom

9 July 2018

1 reference

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Coupling backbone flexibility and amino acid sequence selection in protein design

9 July 2018

1 reference

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Site-specific incorporation of biophysical probes into proteins

9 July 2018

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Decreasing the basicity of the active site base, Lys-258, of Escherichia coli aspartate aminotransferase by replacement with gamma-thialysine

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Hemoglobin allostery: resonance Raman spectroscopy of kinetic intermediates

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation"

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

13C-NMR and transient kinetic studies on lactate dehydrogenase [Cys(13CN)165]. Direct measurement of a rate-limiting rearrangement in protein structure

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Structure of phosphate-free ribonuclease A refined at 1.26 .ANG

9 July 2018

1 reference

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Collective motions in proteins: A covariance analysis of atomic fluctuations in molecular dynamics and normal mode simulations

9 July 2018

1 reference

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Converting trypsin to chymotrypsin: the role of surface loops

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Segmental motion in catalysis: investigation of a hydrogen bond critical for loop closure in the reaction of triosephosphate isomerase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Correlation proton magnetic resonance studies at 250 MHz of bovine pancreatic ribonuclease. II. pH and inhibitor-induced conformational transitions affecting histidine-48 and one tyrosine residue of ribonuclease A

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Non-native side chain IR probe in peptides: ab initio computation and 1D and 2D IR spectral simulation

9 July 2018

1 reference

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Enzyme dynamics along the reaction coordinate: critical role of a conserved residue

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Faithful estimation of dynamics parameters from CPMG relaxation dispersion measurements.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Catalysis by ribonuclease A is limited by the rate of substrate association

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Quantitative analysis of the effect of salt concentration on enzymatic catalysis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Examining the structural and chemical flexibility of the active site base, Lys-258, of Escherichia coli aspartate aminotransferase by replacement with unnatural amino acids

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

The role of mobility in the substrate binding and catalytic machinery of enzymes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3136797

Evidence for flexibility in the function of ribonuclease A

27 September 2018

1 reference

12 December 2020

Introduction of histidine analogs leads to enhanced proton transfer in carbonic anhydrase V

1 reference

12 December 2020

Allostery without conformational change. A plausible model

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12 December 2020

Relaxation Spectra of Ribonuclease. V. The Interaction of Ribonuclease with Cytidylyl-3':5'-cytidine1

1 reference

12 December 2020

Relaxation Spectra of Ribonuclease. IV. The Interaction of Ribonuclease with Cytidine 2':3'-Cyclic Phosphate1

1 reference

12 December 2020

Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A

1 reference

12 December 2020

Relaxation Spectra of Ribonuclease. III. Further Investigation of the Interaction of Ribonuclease and Cytidine 3'-Phosphate

1 reference

12 December 2020

Relaxation Spectra of Ribonuclease. II. Isomerization of Ribonuclease at Neutral pH Values

1 reference

12 December 2020

Fast, Facile, Hypersensitive Assays for Ribonucleolytic Activity

1 reference

12 December 2020

The formation of anhydrochymotrypsin by removing the elements of water from the serine at the active site

1 reference

12 December 2020

Restoration of activity to catalytically deficient mutants of ribulosebisphosphate carboxylase/oxygenase by aminoethylation

1 reference

12 December 2020

10.1016/J.BPJ.2011.05.039

Identifiers

DOI

1 reference

6 August 2017

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6 August 2017

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