(Q35107889)

6 August 2017

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title

Novel IL-12 family members shed light on the orchestration of Th1 responses (English)

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6 August 2017

1

Frank Brombacher

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6 August 2017

Robert A Kastelein

2

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PubMed ID

12697453

6 August 2017

Gottfried Alber

series ordinal

3

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6 August 2017

1 April 2003

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6 August 2017

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6 August 2017

24

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6 August 2017

207-212

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6 August 2017

4

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

6 August 2017

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12 December 2020

Evidence for multiple sites of interaction between IL-12 and its receptor

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12 December 2020

The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40

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12 December 2020

Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells

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12 December 2020

Reduced T helper 1 responses in IL-12 p40 transgenic mice.

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12 December 2020

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

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12 December 2020

Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts

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12 December 2020

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

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12 December 2020

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

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12 December 2020

CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal

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12 December 2020

Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells

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12 December 2020

IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis.

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12 December 2020

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

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12 December 2020

Defective NK cell activity and Th1 response in IL-18-deficient mice

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12 December 2020

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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12 December 2020

Interleukin 12 p40 production by barrier epithelial cells during airway inflammation

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12 December 2020

Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria

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12 December 2020

The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer

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12 December 2020

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

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12 December 2020

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12 December 2020

Effect of interleukin 12 neutralization on host resistance and gamma interferon production in mouse typhoid.

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12 December 2020

Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii

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12 December 2020

A novel function of IL-12p40 as a chemotactic molecule for macrophages

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12 December 2020

Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40.

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12 December 2020

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

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12 December 2020

Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

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12 December 2020

Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit

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12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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12 December 2020

IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18.

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12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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12 December 2020

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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12 December 2020

In vivo production and function of IL-12 p40 homodimers.

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12 December 2020

Conditioning of dendritic cells by pathogen-derived stimuli.

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12 December 2020

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

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12 December 2020

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

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12 December 2020

IL-12 is not required for induction of type 1 cytokine responses in viral infections

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12 December 2020

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

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12 December 2020

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

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12 December 2020

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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12 December 2020

In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70.

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12 December 2020

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

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12 December 2020

Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells

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12 December 2020

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor

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12 December 2020

IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites

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12 December 2020

The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer

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12 December 2020

Alloantigen-reactive Th1 development in IL-12-deficient mice

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12 December 2020

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

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12 December 2020

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

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12 December 2020

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

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12 December 2020

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

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12 December 2020

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

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12 December 2020

Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

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12 December 2020

A profibrotic function of IL-12p40 in experimental pulmonary fibrosis

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12 December 2020

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

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12 December 2020

Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization.

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12 December 2020

Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits

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12 December 2020

Mice lacking IL-12 develop polarized Th1 cells during viral infection

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12 December 2020

IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2.

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12 December 2020

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

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12 December 2020

A protective and agonistic function of IL-12p40 in mycobacterial infection.

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12 December 2020

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans

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12 December 2020

IL-12 is required to maintain a Th1 response during Leishmania major infection.

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12 December 2020

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

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12 December 2020

Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock

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12 December 2020

Interleukin-12: a cytokine at the interface of inflammation and immunity

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12 December 2020

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

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12 December 2020

10.1016/S1471-4906(03)00067-X

Identifiers

DOI

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6 August 2017

1 reference

PubMed ID

12697453