(Q35114631)

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Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608521%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608521%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

neoplastic invasiveness

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inferred from title

4

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10 March 2020

7

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10 March 2020

author name string

Antonios D Konitsiotis

1

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10 March 2020

Shu-Chun Chang

2

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10 March 2020

Biljana Jovanović

3

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10 March 2020

Naoko Masumoto

5

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10 March 2020

Christopher P Palmer

6

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10 March 2020

John R Couchman

8

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10 March 2020

Anthony I Magee

9

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10 March 2020

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7 March 2014

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10 March 2020

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Europe PubMed Central

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10 March 2020

9

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Europe PubMed Central

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10 March 2020

3

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10 March 2020

e89899

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10 March 2020

copyright license

Creative Commons Attribution 4.0 International

7 March 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

1 reference

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9 July 2018

An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions

1 reference

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9 July 2018

The hedgehog processing pathway is required for NSCLC growth and survival

1 reference

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9 July 2018

Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Bioorthogonal chemical tagging of protein cholesterylation in living cells

1 reference

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9 July 2018

Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor

1 reference

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9 July 2018

Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

1 reference

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9 July 2018

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

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9 July 2018

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Acyltransferases for secreted signalling proteins (Review).

1 reference

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9 July 2018

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog: functions and mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

A paracrine requirement for hedgehog signalling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Acyl-CoA:lysophospholipid acyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Ghrelin octanoylation mediated by an orphan lipid transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

The adventures of sonic hedgehog in development and repair. III. Hedgehog processing and biological activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog signaling in development and homeostasis of the gastrointestinal tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Deconstructing the hedgehog pathway in development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog signaling in mammary gland development and breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Activation of the hedgehog pathway in a subset of lung cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog signaling pathway as a therapeutic target in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Sonic hedgehog pathway genes are expressed and transcribed in the adult mouse epididymis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Novel lipid modifications of secreted protein signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog signalling in cancer formation and maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

9 July 2018

Comparative biological responses to human Sonic, Indian, and Desert hedgehog

1 reference

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9 July 2018

Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping

1 reference

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

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9 July 2018

Hollow-spheres: a new model for analyses of differentiation of pancreatic duct epithelial cells

1 reference

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9 July 2018

Induction of osteogenic differentiation by hedgehog proteins.

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9 July 2018

Sonic hedgehog shedding results in functional activation of the solubilized protein.

1 reference

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Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells

1 reference

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27 September 2018

N-Myristoyl transferase-mediated protein labelling in vivo

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Click imaging of biochemical processes in living systems.

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27 September 2018

Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

1 reference

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27 September 2018

Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3946499

27 September 2018

Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

1 reference

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27 September 2018

Frequent requirement of hedgehog signaling in non-small cell lung carcinoma

1 reference

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12 December 2020

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10.1371/JOURNAL.PONE.0089899

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608521%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

2014PLoSO...989899K

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24 November 2022

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10 March 2020

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Europe PubMed Central

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10 March 2020

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