(Q35119367)

6 August 2017

1 reference

title

The p38 mitogen-activated protein kinase pathway and its role in interferon signaling (English)

1 reference

regulation of gene expression

6 August 2017

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12725866

29 December 2023

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

29 December 2023

author name string

Leonidas C. Platanias

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12725866

29 December 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12725866

29 December 2023

publication date

1 May 2003

1 reference

full work available at URL

6 August 2017

https://api.elsevier.com/content/article/PII:S0163725803000160?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

https://api.elsevier.com/content/article/PII:S0163725803000160?httpAccept=text/plain

29 December 2023

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

Pharmacology & Therapeutics

29 December 2023

published in

1 reference

6 August 2017

volume

98

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6 August 2017

issue

2

1 reference

6 August 2017

page(s)

129-142

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Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta

6 August 2017

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IFN-gamma activates the C3G/Rap1 signaling pathway

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Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses

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RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

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7 January 2021

The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein

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STATs and gene regulation

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Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

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Serine phosphorylation of STATs

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7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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7 January 2021

Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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7 January 2021

Structure of the human type-I interferon gene cluster determined from a YAC clone contig

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7 January 2021

Cloning and Expression of a Long Form of the β Subunit of the Interferon αβ Receptor That Is Required for Signaling

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7 January 2021

Engagement of the CrkL adapter in interleukin-5 signaling in eosinophils

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7 January 2021

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

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7 January 2021

Activation of a CrkL-stat5 signaling complex by type I interferons.

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7 January 2021

Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway

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7 January 2021

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

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7 January 2021

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

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7 January 2021

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

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7 January 2021

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

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7 January 2021

Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes

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7 January 2021

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

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7 January 2021

Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells

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7 January 2021

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

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7 January 2021

Cytokine therapeutics: lessons from interferon alpha

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7 January 2021

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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7 January 2021

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

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7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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7 January 2021

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

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7 January 2021

Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

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7 January 2021

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

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7 January 2021

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7 January 2021

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations

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7 January 2021

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

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7 January 2021

Thrombin induces activation of p38 MAP kinase in human platelets

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7 January 2021

Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor

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7 January 2021

Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase

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7 January 2021

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

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7 January 2021

Interferon alfa-2a combined with phototherapy in the treatment of cutaneous T-cell lymphoma.

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7 January 2021

Sounding the alarm: protein kinase cascades activated by stress and inflammation

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7 January 2021

Interferon receptors.

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7 January 2021

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

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7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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7 January 2021

The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1.

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7 January 2021

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

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7 January 2021

Pathogenesis, natural history, treatment, and prevention of hepatitis C.

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7 January 2021

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

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7 January 2021

Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

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7 January 2021

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster

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7 January 2021

Maintenance treatment with recombinant interferon alfa-2b in patients with multiple myeloma responding to conventional induction chemotherapy

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7 January 2021

A novel viral oncogene with structural similarity to phospholipase C

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7 January 2021

The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells

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7 January 2021

Interferon alfacon-1: a review of its pharmacology and therapeutic efficacy in the treatment of chronic hepatitis C.

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7 January 2021

SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases

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7 January 2021

p95(vav) associates with the type I interferon (IFN) receptor and contributes to the antiproliferative effect of IFN-alpha in megakaryocytic cell lines

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7 January 2021

Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase

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7 January 2021

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

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7 January 2021

The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a thresh

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7 January 2021

Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression

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7 January 2021

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The human interferon alpha/beta receptor: characterization and molecular cloning

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7 January 2021

Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

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7 January 2021

The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism

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7 January 2021

Interferon standards and general abbreviations

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7 January 2021

The human interferon alpha species and receptors

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7 January 2021

Interferons and their actions

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7 January 2021

The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor

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7 January 2021

Signaling pathways activated by interferons

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7 January 2021

Expression of the IFN alpha receptor in hairy cell leukaemia

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7 January 2021

Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor

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7 January 2021

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

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7 January 2021

CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors

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7 January 2021

Heat-shock proteins and platelet function

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7 January 2021

Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors

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7 January 2021

Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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7 January 2021

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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7 January 2021

The evolution of the type I interferons

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7 January 2021

Mitogen-activated protein kinase pathways

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7 January 2021

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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7 January 2021

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

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7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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7 January 2021

Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

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7 January 2021

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

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7 January 2021

A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini

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7 January 2021

Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets

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7 January 2021

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

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7 January 2021

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

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7 January 2021

Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma

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7 January 2021

How cells respond to interferons

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7 January 2021

Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade

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7 January 2021

p38-2, a novel mitogen-activated protein kinase with distinct properties.

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7 January 2021

Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative

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7 January 2021

The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

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7 January 2021

p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6.

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7 January 2021

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

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7 January 2021

Tumor necrosis factor-alpha mediates antiapoptotic signals partially via p38 MAP kinase activation in human eosinophils

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7 January 2021

Interaction of the transcriptional activator Stat-2 with the type I interferon receptor

1 reference

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7 January 2021

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

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7 January 2021

The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase

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7 January 2021

Activation of the p38 mitogen-activated protein kinase by type I interferons

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7 January 2021

Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathway

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7 January 2021

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.

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7 January 2021

Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA

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7 January 2021

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

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7 January 2021

Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

What is new in the treatment of multiple sclerosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Interferon-alpha therapy for chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Engagement of Gab1 and Gab2 in erythropoietin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Regulation of the MEF2 family of transcription factors by p38

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900016-0

7 January 2021

The genes of interferons and interferon-related factors: localization and relationships with chromosome aberrations in cancer

46

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors

29 December 2023

113

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia

29 December 2023

131

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins

29 December 2023

144

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

29 December 2023

151

1 reference

https://api.crossref.org/works/10.1016/S0163-7258(03)00016-0

29 December 2023

Identifiers

1 reference

6 August 2017

1 reference