(Q35121667)

6 August 2017

title

Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features (English)

1 reference

6 August 2017

Vinod K Batra

1

1 reference

6 August 2017

David D Shock

2

1 reference

6 August 2017

Rajendra Prasad

3

1 reference

6 August 2017

William A Beard

4

1 reference

6 August 2017

Esther W Hou

5

1 reference

6 August 2017

Lars C Pedersen

6

1 reference

6 August 2017

Jane M Sayer

7

1 reference

6 August 2017

Haruhiko Yagi

8

1 reference

6 August 2017

Subodh Kumar

9

1 reference

6 August 2017

Donald M Jerina

10

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6 August 2017

Samuel H Wilson

11

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6 August 2017

language of work or name

English

0 references

publication date

1 November 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

103

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6 August 2017

issue

46

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6 August 2017

page(s)

17231-17236

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Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

6 August 2017

cites work

1 reference

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Structure and mechanism of DNA polymerase Beta.

9 July 2018

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Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Structural Insights into the Origins of DNA Polymerase Fidelity

9 July 2018

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Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene

9 July 2018

1 reference

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A role for DNA polymerase beta in mutagenic UV lesion bypass

9 July 2018

1 reference

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Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability

9 July 2018

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Specialized DNA polymerases, cellular survival, and the genesis of mutations

9 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

A multistep damage recognition mechanism for global genomic nucleotide excision repair

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Variability in nucleotide excision repair and cancer risk: a review

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Polycyclic aromatic hydrocarbons in the diet.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

DNA damage recognition during nucleotide excision repair in mammalian cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Cytosine deamination in mismatched base pairs.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Exceptionally high tumor-initiating activity of benzo(c)phenanthrene bay-region diol-epoxides on mouse skin.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Sites of termination of in vitro DNA synthesis on ultraviolet- and N-acetylaminofluorene-treated phi X174 templates by prokaryotic and eukaryotic DNA polymerases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Structural and thermodynamic studies on the adenine.guanine mismatch in B-DNA

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Covalent bonding of bay-region diol epoxides to nucleic acids

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

The 'A rule' of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions?

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Site-specific mutagenesis in Escherichia coli by N2-deoxyguanosine adducts derived from the highly carcinogenic fjord-region benzo[c]phenanthrene 3,4-diol 1,2-epoxides

9 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Repair of DNA lesions induced by polycyclic aromatic hydrocarbons in human cell-free extracts: involvement of two excision repair mechanisms in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

In vitro bypass replication of the cisplatin-d(GpG) lesion by calf thymus DNA polymerase beta and human immunodeficiency virus type I reverse transcriptase is highly mutagenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Cyclohexene ring and Fjord region twist inversion in stereoisomeric DNA adducts of enantiomeric benzo[c]phenanthrene diol epoxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

O(6)-allyl protected deoxyguanosine adducts of polycyclic aromatic hydrocarbons as building blocks for the synthesis of oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Novel stereoselective control over cis vs trans opening of benzo[c]phenanthrene 3,4-diol 1,2-epoxides by the exocyclic N(2)-amino group of deoxyguanosine in the presence of hexafluoropropan-2-ol

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605069103

Mutagenicity of the enantiomers of the diastereomeric bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides in bacterial and mammalian cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Effects of benzo[a]pyrene-DNA adducts on a reconstituted replication system

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1630674

Structural Alignments of (+)- and (-)-trans-anti-Benzo[a]pyrene-dG Adducts Positioned at a DNA Replication Fork Junction

27 September 2018

1 reference

12 December 2020

The role of DNA adducts in chemical carcinogenesis

1 reference

12 December 2020

Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models

1 reference

12 December 2020

Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2'-deoxyguanosine DNA adducts: marked effects of host cell, sequence context, and chirality

1 reference

12 December 2020

Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots

1 reference

12 December 2020

Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0605069103

1 reference

6 August 2017

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1 reference

6 August 2017

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