(Q35121737)

6 August 2017

1 reference

title

The t(8;21) fusion protein contacts co-repressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor (English)

1 reference

6 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12732181

chromosomal translocation

30 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12732181

30 December 2023

transcription

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12732181

neoplastic gene expression regulation

30 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12732181

30 December 2023

1 reference

https://api.crossref.org/works/10.1016/S1079-9796(03)00021-4

30 December 2023

1 reference

https://api.crossref.org/works/10.1016/S1079-9796(03)00021-4

30 December 2023

author name string

Joseph Amann

3

1 reference

6 August 2017

Brenda Irvin

4

1 reference

6 August 2017

Kristie Durst

5

1 reference

6 August 2017

Bryan Linggi

6

1 reference

6 August 2017

Scott W. Hiebert

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12732181

30 December 2023

Edward F. Reed-Inderbitzin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12732181

30 December 2023

language of work or name

1 reference

1 March 2003

1 reference

full work available at URL

6 August 2017

https://api.elsevier.com/content/article/PII:S1079979603000214?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S1079-9796(03)00021-4

https://api.elsevier.com/content/article/PII:S1079979603000214?httpAccept=text/plain

30 December 2023

1 reference

https://api.crossref.org/works/10.1016/S1079-9796(03)00021-4

Blood Cells, Molecules and Diseases

30 December 2023

published in

1 reference

6 August 2017

30

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6 August 2017

2

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6 August 2017

177-183

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Oncogenic transcription factors in the human acute leukemias

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Cooperative binding of Ets-1 and core binding factor to DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Groucho-dependent and -independent repression activities of Runt domain proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Multiple regions of ETO cooperate in transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

1 reference

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Inhibition of v-Abl transformation by p53 and p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

Analysis of p53 gene mutations in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

1 reference

https://api.crossref.org/works/10.1016%2FS1079-9796%2803%2900021-4

7 January 2021

AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia

69

1 reference

https://api.crossref.org/works/10.1016/S1079-9796(03)00021-4

30 December 2023

Identifiers

1 reference

6 August 2017

1 reference