(Q35126550)

6 August 2017

title

Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites (English)

1 reference

6 August 2017

1 reference

1 reference

6

Michael A Matthay

1 reference

6 August 2017

3

Andrey A Komissarov

1 reference

6 August 2017

Hong-Long Ji

1

1 reference

6 August 2017

Runzhen Zhao

series ordinal

2

1 reference

6 August 2017

Yongchang Chang

series ordinal

4

1 reference

6 August 2017

Yongfeng Liu

series ordinal

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

2 January 2015

1 reference

6 August 2017

number of pages

15

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

6 August 2017

volume

290

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6 August 2017

issue

9

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6 August 2017

page(s)

5241-5255

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Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency

6 August 2017

cites work

1 reference

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Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.

13 July 2018

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13 July 2018

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Tissue plasminogen activator attenuates ventilator-induced lung injury in rats

13 July 2018

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Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition

13 July 2018

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Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice

13 July 2018

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Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury

13 July 2018

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The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation

13 July 2018

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Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits

13 July 2018

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Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

13 July 2018

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ENaC at the cutting edge: regulation of epithelial sodium channels by proteases

13 July 2018

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Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Activation of the epithelial sodium channel (ENaC) by serine proteases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability

13 July 2018

1 reference

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The contribution of epithelial sodium channels to alveolar function in health and disease.

13 July 2018

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Intracellular sodium regulates proteolytic activation of the epithelial sodium channel

13 July 2018

1 reference

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Patterns of alveolar fluid clearance in heart failure

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

The pathogenesis of pleural space loculation and fibrosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Epithelial sodium channels in the adult lung--important modulators of pulmonary health and disease.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Mechanisms of neurogenic pulmonary edema development.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

The plasminogen activation system in lung disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Regulation of the epithelial Na+ channel by peptidases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Urokinase-type plasminogen activator

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Clinical practice. Acute pulmonary edema

13 July 2018

1 reference

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The epithelial sodium channel: activation by membrane-bound serine proteases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Serine protease activation of near-silent epithelial Na+ channels

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Stress-dose corticosteroid therapy for sepsis and acute lung injury or acute respiratory distress syndrome in critically ill adults

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Plasminogen activators in inflammation and sepsis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Na self inhibition of human epithelial Na channel: temperature dependence and effect of extracellular proteases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Lung epithelial fluid transport and the resolution of pulmonary edema

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Jet and ultrasonic nebulization of single chain urokinase plasminogen activator (scu-PA).

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Tissue plasminogen activator (tPA) inhibits interleukin-1 induced acute lung leak

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Kinetic interconversion of rat and bovine homologs of the alpha subunit of an amiloride-sensitive Na+ channel by C-terminal truncation of the bovine subunit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Origins of the specificity of tissue-type plasminogen activator

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Abnormalities of pathways of fibrin turnover in the human pleural space

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Treatment of thoracic multiloculated empyemas with intracavitary urokinase: a prospective study.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Fibrinolytic activity in bronchoalveolar lavage of baboons with diffuse alveolar damage: trends in two forms of lung injury

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Beta-adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failure

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

SitePredicting the cleavage of proteinase substrates

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

ENaC proteolytic regulation by channel-activating protease 2.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Transgenic tissue-type plasminogen activator expression improves host defense during Klebsiella pneumonia.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Administration of exogenous tissue plasminogen activator reduces oedema in mice lacking the tissue plasminogen activator gene

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Influenza virus inhibits ENaC and lung fluid clearance

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Point mutations in the post-M2 region of human alpha-ENaC regulate cation selectivity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Peptide inhibition of constitutively activated epithelial Na(+) channels expressed in Xenopus oocytes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Optimal subsite occupancy and design of a selective inhibitor of urokinase.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342445

Localization of plasminogen activator activity within normal and injured lungs by in situ zymography

27 September 2018

1 reference

12 December 2020

Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease

1 reference

12 December 2020

Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome

1 reference

12 December 2020

Alveolar epithelial cell plasminogen activator. Characterization and regulation

1 reference

12 December 2020

Expression of urokinase-type plasminogen activator by rat pulmonary alveolar epithelial cells

1 reference

12 December 2020

Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome

1 reference

12 December 2020

Lung capillary endothelial cells produce and secrete urokinase-type plasminogen activator

1 reference

12 December 2020

Pathways of fibrin turnover of human pleural mesothelial cells in vitro

1 reference

12 December 2020

Disordered pathways of fibrin turnover in lung lavage of premature infants with respiratory distress syndrome

1 reference

12 December 2020

Effects of intrapleural heparin or urokinase on the extent of tetracycline-induced pleural disease

1 reference

12 December 2020

Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen

1 reference

12 December 2020

Elevation of serum levels of urokinase-type plasminogen activator and its receptor is associated with disease progression and prognosis in patients with prostate cancer

1 reference

12 December 2020

Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury

1 reference

12 December 2020

Intrapleural activation, processing, efficacy, and duration of protection of single-chain urokinase in evolving tetracycline-induced pleural injury in rabbits

1 reference

12 December 2020

Identification of the mechanism responsible for the increased fibrin specificity of TNK-tissue plasminogen activator relative to tissue plasminogen activator

1 reference

12 December 2020

Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation

1 reference

12 December 2020

Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis

1 reference

12 December 2020

Intrapleural urokinase in the treatment of complicated parapneumonic pleural effusions and empyema

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.623496

1 reference

6 August 2017

1 reference

6 August 2017

1 reference