(Q35126722)

6 August 2017

title

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity (English)

1 reference

Magdalena Makowska-Grzyska

6 August 2017

author

1

object named as

Magdalena Makowska-Grzyska

0 references

Andrzej Joachimiak

11

object named as

Andrzej Joachimiak

1 reference

6 August 2017

4

Jerzy Osipiuk

1 reference

6 August 2017

author name string

Magdalena Makowska-Grzyska

1

1 reference

6 August 2017

Youngchang Kim

2

1 reference

6 August 2017

Natalia Maltseva

3

1 reference

6 August 2017

Minyi Gu

5

1 reference

6 August 2017

Minjia Zhang

6

1 reference

6 August 2017

Kavitha Mandapati

7

1 reference

6 August 2017

Deviprasad R Gollapalli

8

1 reference

6 August 2017

Suresh Kumar Gorla

9

1 reference

6 August 2017

Lizbeth Hedstrom

10

1 reference

6 August 2017

language of work or name

English

0 references

publication date

8 January 2015

1 reference

Journal of Biological Chemistry

6 August 2017

published in

1 reference

6 August 2017

volume

290

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6 August 2017

issue

9

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6 August 2017

page(s)

5893-5911

1 reference

Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.

6 August 2017

cites work

1 reference

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Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

28 July 2018

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Structure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenase

28 July 2018

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Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.

28 July 2018

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Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes

28 July 2018

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Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis

28 July 2018

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Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.

28 July 2018

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Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes

28 July 2018

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Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase

28 July 2018

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Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase

28 July 2018

1 reference

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The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors

28 July 2018

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Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases

28 July 2018

1 reference

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A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase

28 July 2018

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Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis

28 July 2018

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28 July 2018

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Antibiotics for emerging pathogens

28 July 2018

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Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase

28 July 2018

1 reference

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IMP dehydrogenase: structure, mechanism, and inhibition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover

28 July 2018

1 reference

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Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis

28 July 2018

1 reference

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

28 July 2018

1 reference

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HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

28 July 2018

1 reference

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The Structural Biology Center 19ID undulator beamline: facility specifications and protein crystallographic results.

28 July 2018

1 reference

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Coot: model-building tools for molecular graphics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Refinement of macromolecular structures by the maximum-likelihood method

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism

28 July 2018

1 reference

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The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase

28 July 2018

1 reference

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Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis

28 July 2018

1 reference

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The TIM-barrel fold: a versatile framework for efficient enzymes

28 July 2018

1 reference

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

28 July 2018

1 reference

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Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design

28 July 2018

1 reference

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The structure of a domain common to archaebacteria and the homocystinuria disease protein

28 July 2018

1 reference

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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

28 July 2018

1 reference

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Multiple sequence alignment with hierarchical clustering

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Deciphering key features in protein structures with the new ENDscript server

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Pharmacophore binding motifs for nicotinamide adenine dinucleotide analogues across multiple protein families: a detailed contact-based analysis of the interaction between proteins and NAD(P) cofactors

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

High-throughput protein purification and quality assessment for crystallization

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Linking distinct conformations of nicotinamide adenine dinucleotide with protein fold/function.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Overview of the CCP4 suite and current developments

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Asp338 controls hydride transfer in Escherichia coli IMP dehydrogenase

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Biochemical analysis of the modular enzyme inosine 5'-monophosphate dehydrogenase

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

Unusual conformation of nicotinamide adenine dinucleotide (NAD) bound to diphtheria toxin: a comparison with NAD bound to the oxidoreductase enzymes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4342496

PURINE N-OXIDES. XII. PHOTOCHEMICAL CHANGES INDUCED BY ULTRAVIOLET RADIATION

27 September 2018

1 reference

12 December 2020

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain

1 reference

12 December 2020

Integration of PCR fragments at any specific site within cloning vectors without the use of restriction enzymes and DNA ligase

1 reference

12 December 2020

Differential signatures of bacterial and mammalian IMP dehydrogenase enzymes

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.619767

1 reference

6 August 2017

1 reference

6 August 2017

1 reference