(Q35128610)

6 August 2017

1 reference

title

Implications of genetic testing in the management of colorectal cancer (English)

1 reference

6 August 2017

Implications of Genetic Testing in the Management of Colorectal Cancer (English)

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

2 January 2024

1 reference

1 reference

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

2 January 2024

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

2 January 2024

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

2 January 2024

2

Heinz-Josef Lenz

1 reference

6 August 2017

Jan Stoehlmacher

1

1 reference

6 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12749725

2 January 2024

publication date

1 January 2003

1 reference

Molecular Diagnosis and Therapy

6 August 2017

1 reference

6 August 2017

3

1 reference

6 August 2017

2

1 reference

6 August 2017

73-88

1 reference

https://scigraph.springernature.com/pub.10.2165/00129785-200303020-00001

6 August 2017

0 references

cites work

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

1 reference

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21 January 2018

Colorectal cancer

1

1 reference

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The prognostic significance of tumor location and bowel obstruction in Dukes B and C colorectal cancer. Findings from the NSABP clinical trials

2 January 2024

3

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Impact of variability among surgeons on postoperative morbidity and mortality and ultimate survival

2 January 2024

4

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Tumour markers of prognosis in colorectal cancer

2 January 2024

5

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

2 January 2024

6

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues

2 January 2024

7

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

2 January 2024

8

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Allelic loss of chromosome 18q and prognosis in colorectal cancer

2 January 2024

9

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

The DCC protein and prognosis in colorectal cancer

2 January 2024

10

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer

2 January 2024

11

1 reference

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Molecular predictors of survival after adjuvant chemotherapy for colon cancer

2 January 2024

12

1 reference

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Cancer prognostics: past, present and p27

2 January 2024

13

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases

2 January 2024

14

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

2 January 2024

15

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Down-regulation of p27 is a significant predictor of poor overall survival and may facilitate metastasis in colorectal carcinomas

2 January 2024

16

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization

2 January 2024

17

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

2 January 2024

18

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Microsatellite instability in cancer of the proximal colon

2 January 2024

19

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

2 January 2024

20

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer

2 January 2024

23

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers

2 January 2024

24

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

2 January 2024

25

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis.

2 January 2024

26

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor

2 January 2024

27

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

2 January 2024

28

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

P53 in tumour pathology: can we trust immunocytochemistry?

2 January 2024

29

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

p53 and behaviour of colorectal cancer

2 January 2024

32

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

2 January 2024

33

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Pharmacogenomics: translating functional genomics into rational therapeutics

2 January 2024

34

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics.

2 January 2024

35

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1.

2 January 2024

36

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity

2 January 2024

38

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Cyclopenta(f)isoquinoline derivatives designed to bind specifically to native deoxyribonucleic acid. 3. Interaction of 6-carbamylmethyl-8-methyl-7H-cyclopenta(f)isoquinolin-3(2H)-one with deoxyribonucleic acids and polydeoxyribonucleotides

2 January 2024

40

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Biochimica et Biophysica Acta

2 January 2024

41

473

73

Danenberg

1977

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin

2 January 2024

42

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy

2 January 2024

43

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Microdissection is essential for gene expression profiling of clinically resected cancer tissues

2 January 2024

44

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue

2 January 2024

45

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA.

2 January 2024

49

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase

2 January 2024

50

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles

2 January 2024

52

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations.

2 January 2024

53

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Novel thymidylate synthase enhancer region alleles in African populations

2 January 2024

54

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

2 January 2024

55

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

2 January 2024

58

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

2 January 2024

59

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

2 January 2024

60

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Growth factor-mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29-nucleotide sequence in the 3'-untranslated region

2 January 2024

63

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Dissociation of basal turnover and cytokine-induced transcript stabilization of the human cyclooxygenase-2 mRNA by mutagenesis of the 3'-untranslated region

2 January 2024

64

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy

2 January 2024

66

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy

2 January 2024

71

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer

2 January 2024

72

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy

2 January 2024

73

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Kinetic studies of thymidine phosphorylase from mouse liver

2 January 2024

74

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial

2 January 2024

76

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma

2 January 2024

78

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Population study of dihydropyrimidine dehydrogenase in cancer patients

2 January 2024

80

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Nomenclature for human DPYD alleles.

2 January 2024

81

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

2 January 2024

82

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency

2 January 2024

85

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Characterization of dihydropyrimidine dehydrogenase on immunohistochemistry in colon carcinoma, and correlation between immunohistochemical score and protein level or messenger RNA expression

2 January 2024

86

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

The role of dUTPase and uracil-DNA repair in cancer chemotherapy

2 January 2024

89

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Mechanisms of resistance to topoisomerase inhibitors.

2 January 2024

90

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

2 January 2024

Molecular Pharmacology

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34

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Eng

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1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group

2 January 2024

93

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen

2 January 2024

94

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer

2 January 2024

95

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

2 January 2024

97

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Drug Metabolism and Disposition

2 January 2024

98

29

596

Innocenti

2001

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

2 January 2024

99

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

2 January 2024

100

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

2 January 2024

101

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

2 January 2024

102

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler-Najjar syndrome type II

2 January 2024

103

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

2 January 2024

104

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome.

2 January 2024

106

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Drug Metabolism and Disposition

2 January 2024

108

26

769

Haaz

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1 reference

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Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

2 January 2024

110

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice

2 January 2024

111

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https://api.crossref.org/works/10.2165/00129785-200303020-00001

Nucleotide excision repair. II: From yeast to mammals

2 January 2024

115

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https://api.crossref.org/works/10.2165/00129785-200303020-00001

Glutathione transferases and cancer

2 January 2024

119

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Reduced topoisomerase II and elevated alpha class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C.

2 January 2024

120

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2 January 2024

Molecular Pharmacology

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https://api.crossref.org/works/10.2165/00129785-200303020-00001

Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells

2 January 2024

122

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.

2 January 2024

124

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

2 January 2024

125

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa

2 January 2024

126

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105

2 January 2024

127

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer

2 January 2024

128

1 reference

https://api.crossref.org/works/10.2165/00129785-200303020-00001

2 January 2024

Identifiers

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference