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Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
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scholarly article
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Q5412157
PubMed ID
21639134
retrieved
6 August 2017
title
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
(English)
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Q5412157
PubMed ID
21639134
retrieved
6 August 2017
author
Benjamin Cravatt
series ordinal
8
object named as
Benjamin F Cravatt
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Q5412157
PubMed ID
21639134
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6 August 2017
author name string
Daniel A Bachovchin
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1
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Q5412157
PubMed ID
21639134
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6 August 2017
Andrea M Zuhl
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2
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Q5412157
PubMed ID
21639134
retrieved
6 August 2017
Anna E Speers
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3
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Q5412157
PubMed ID
21639134
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6 August 2017
Monique R Wolfe
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4
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Q5412157
PubMed ID
21639134
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6 August 2017
Eranthie Weerapana
series ordinal
5
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Q5412157
PubMed ID
21639134
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6 August 2017
Steven J Brown
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6
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Q5412157
PubMed ID
21639134
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6 August 2017
Hugh Rosen
series ordinal
7
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Q5412157
PubMed ID
21639134
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6 August 2017
language of work or name
English
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publication date
30 June 2011
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Q5412157
PubMed ID
21639134
retrieved
6 August 2017
published in
Journal of Medicinal Chemistry
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Q5412157
PubMed ID
21639134
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6 August 2017
volume
54
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Q5412157
PubMed ID
21639134
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6 August 2017
page(s)
5229-5236
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Q5412157
PubMed ID
21639134
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6 August 2017
issue
14
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Q5412157
PubMed ID
21639134
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6 August 2017
describes a project that uses
ImageJ
1 reference
stated in
Q5412157
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3144155/fullTextXML
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cites work
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors
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PubMed Central
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13 July 2018
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Quantitative reactivity profiling predicts functional cysteines in proteomes
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PubMed Central
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13 July 2018
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells
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13 July 2018
Serine/threonine phosphatases: mechanism through structure
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13 July 2018
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Enantioselective nucleophilic catalysis: the synthesis of aza-beta-lactams through [2+2] cycloadditions of ketenes with azo compounds
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Disparate proteome reactivity profiles of carbon electrophiles
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13 July 2018
Structural mechanism of demethylation and inactivation of protein phosphatase 2A
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13 July 2018
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
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13 July 2018
An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics
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13 July 2018
Irreversible inhibitors of serine, cysteine, and threonine proteases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
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13 July 2018
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
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PubMed Central
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13 July 2018
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Activity-based protein profiling: the serine hydrolases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Regulation of protein kinase cascades by protein phosphatase 2A.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
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13 July 2018
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
retrieved
13 July 2018
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
retrieved
27 September 2018
A streamlined platform for high-content functional proteomics of primary human specimens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
retrieved
27 September 2018
Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
retrieved
27 September 2018
Profiling serine hydrolase activities in complex proteomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3144155
retrieved
27 September 2018
Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21639134
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21639134
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21639134
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/JM200502U
1 reference
stated in
Q5412157
PubMed ID
21639134
retrieved
6 August 2017
PMCID
3144155
1 reference
stated in
Q5412157
PubMed ID
21639134
retrieved
6 August 2017
PubMed ID
21639134
1 reference
stated in
Q5412157
PubMed ID
21639134
retrieved
6 August 2017
ResearchGate publication ID
51189465
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