(Q35131239)

6 August 2017

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title

Adaptive and innate immune responses to gene transfer vectors: role of cytokines and chemokines in vector function (English)

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6 August 2017

Chen D

1

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6 August 2017

Murphy B

series ordinal

2

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6 August 2017

Sung R

series ordinal

3

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6 August 2017

Bromberg JS

series ordinal

4

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6 August 2017

publication date

1 June 2003

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6 August 2017

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6 August 2017

volume

10

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6 August 2017

issue

11

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6 August 2017

page(s)

991-998

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MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Recombinant adeno-associated virus for muscle directed gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Immune response to recombinant adenovirus in humans: capsid components from viral input are targets for vector-specific cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Adenovirus hexon protein is a potent adjuvant for activation of a cellular immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

"Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

The role of CpG motifs in immunostimulation and gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from Mycobacterium bovis BCG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Type I interferon-mediated stimulation of T cells by CpG DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Noncytolytic control of viral infections by the innate and adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Innate immunity: impact on the adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

MAP kinases in the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Promotion of alpha/beta interferon induction during in vivo viral infection through alpha/beta interferon receptor/STAT1 system-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Innate immunity: the missing link in neuroprotection and neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

The double-stranded RNA-dependent protein kinase PKR: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

PKR; a sentinel kinase for cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Interferon regulatory factor-3 is an in vivo target of DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

A role for DNA-PK in retroviral DNA integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Chemokines: a new classification system and their role in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Chemokines as regulators of T cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Stimulatory and inhibitory action of cytokines on the regulation of hCMV-IE promoter activity in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC I promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Systemic production of IL-12 by naked DNA mediated gene transfer: toxicity and attenuation of transgene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

A regulated, NFkappaB-assisted import of plasmid DNA into mammalian cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Immunization through dermal delivery of protein-encoding DNA: a role for migratory dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

TNFalpha and IFNgamma induced by innate anti-adenoviral immune responses inhibit adenovirus-mediated transgene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Repression of retrovirus-mediated transgene expression by interferons: implications for gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302031

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302031

1 reference

6 August 2017

1 reference