(Q35140091)

6 August 2017

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title

Antagonists of the corticotropin releasing factor receptor (English)

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6 August 2017

John Saunders

1

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6 August 2017

John Williams

series ordinal

2

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6 August 2017

publication date

1 January 2003

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Progress in medicinal chemistry

6 August 2017

published in

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6 August 2017

volume

41

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6 August 2017

page(s)

195-247

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Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents

6 August 2017

cites work

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7 January 2021

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

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7 January 2021

Neural control of the pituitary gland.

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7 January 2021

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

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7 January 2021

Expression cloning of a human corticotropin-releasing-factor receptor

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7 January 2021

Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy

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7 January 2021

Cloning and characterization of human urocortin [published erratum appears in Endocrinoogy 1996 Sep;137(9):3896]

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7 January 2021

Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

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7 January 2021

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

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7 January 2021

Heading off a web of deceit

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7 January 2021

Synthetic Competitive Antagonists of Corticotropin-Releasing Factor: Effect on ACTH Secretion in the Rat

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7 January 2021

Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor

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7 January 2021

Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2beta-selective antisauvagine-30

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7 January 2021

A role for a helical connector between two receptor binding sites of a long-chain peptide hormone.

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7 January 2021

Alanine series of ovine corticotropin releasing factor (oCRF): a structure-activity relationship study

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7 January 2021

Constrained corticotropin releasing factor antagonists (astressin analogues) with long duration of action in the rat

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7 January 2021

Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics.

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7 January 2021

Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

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7 January 2021

A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology

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7 January 2021

Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression

1 reference

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7 January 2021

Cloning and characterization of a short variant of the corticotropin-releasing factor receptor subtype from rat amygdala

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7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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7 January 2021

The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residues

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Extracellular cysteines of the corticotropin-releasing factor receptor are critical for ligand interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Functional and protein chemical characterization of the N-terminal domain of the rat corticotropin-releasing factor receptor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Structure-function relationship of different domains of the rat corticotropin-releasing factor receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The first extracellular domain of corticotropin releasing factor-R1 contains major binding determinants for urocortin and astressin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Localization of Ligand-Binding Domains of Human Corticotropin-Releasing Factor Receptor: A Chimeric Receptor Approach

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The role of the fourth extracellular domain of the rat corticotropin-releasing factor receptor type 1 in ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Identification of amino acids in the N-terminal domain of corticotropin-releasing factor receptor 1 that are important determinants of high-affinity ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Constitutive activation of tethered-peptide/corticotropin-releasing factor receptor chimeras

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Bi

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: novel synthesis via cyclization of N-acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-releasing factor-1 (CRF(1)) receptor antagonist activities

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Pharmacophore development for corticotropin-releasing hormone: new insights into inhibitor activity.

1 reference

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7 January 2021

Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists

1 reference

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7 January 2021

4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

1 reference

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7 January 2021

Design, synthesis and structure-affinity relationships of 4-methylidenepiperidine and 4-aryl-1,2,3,6-tetrahydropyridine derivatives as corticotropin-releasing factor1 receptor antagonists

1 reference

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7 January 2021

Synthesis and structure-affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor(1) receptor antagonists.

1 reference

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7 January 2021

Structure-activity studies on 4-substituted-2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists

1 reference

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7 January 2021

Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies

1 reference

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7 January 2021

In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor(1) receptor antagonists: aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d)pyrimidine, -purin-8-one, and -7H-pyrr

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Arylamidrazones as novel corticotropin releasing factor receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors

1 reference

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7 January 2021

Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor

1 reference

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7 January 2021

The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Behavioral effects of central administration of the novel CRF antagonist astressin in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Involvement of corticotropin-releasing factor subtype 1 receptor in the acquisition phase of learned helplessness in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Involvement of the hypothalamus-pituitary-adrenal axis in antidepressant activity of corticotropin-releasing factor subtype 1 receptor antagonists in the rat learned helplessness test.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Stress, corticotropin-releasing factor, and drug addiction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Stress and cocaine addiction

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

The cocaine-induced elevation of plasma corticosterone is mediated by endogenous corticotropin-releasing factor (CRF) in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Corticotropin-releasing factor receptor type 1 mediates stress-induced relapse to cocaine-conditioned place preference in rats

1 reference

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7 January 2021

The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats.

1 reference

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7 January 2021

CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Effects of CP-154,526 on responding during extinction from cocaine self-administration in rats

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7 January 2021

Role of corticotropin-releasing factor receptor-1 in opiate withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Involvement of corticotropin-releasing factor receptor subtype 1 in morphine withdrawal regulation of the brain noradrenergic system

1 reference

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7 January 2021

Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats

1 reference

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7 January 2021

Peripheral corticotropin-releasing factor induces diarrhea in rats: role of CRF1 receptor in fecal watery excretion

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Amino acids are compatible osmolytes for volume recovery after hypertonic shrinkage in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2802%2941006-5

7 January 2021

10.1016/S0079-6468(02)41006-5

Identifiers

DOI

1 reference

6 August 2017

1 reference