(Q35145998)

6 August 2017

title

Direct activation of the apoptosis machinery as a mechanism to target cancer cells (English)

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6 August 2017

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Jack T Nguyen

1

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6 August 2017

James A Wells

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

13 June 2003

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

100

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6 August 2017

issue

13

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6 August 2017

page(s)

7533-7538

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Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Apoptosis: a link between cancer genetics and chemotherapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

The expanding role of mitochondria in apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Signaling pathways in apoptosis as potential targets for cancer therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Chemical genetic approaches for the elucidation of signaling pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Apoptotic pathways: paper wraps stone blunts scissors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Death by design: mechanism and control of apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Mitochondria and apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Caspases: Intracellular Signaling by Proteolysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164621

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1031631100

21 January 2018

Identifiers

DOI

10.1073/PNAS.1031631100

1 reference

6 August 2017

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1 reference

6 August 2017

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