(Q35150010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

review article

1 reference

title

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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3

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4 November 2019

author name string

Davide Agnello

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Carla S R Lankford

2

1 reference

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4 November 2019

Akio Morinobu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Massimo Gadina

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

John J O'Shea

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

David M Frucht

7

1 reference

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4 November 2019

publication date

1 May 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Immunology

4 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

23

1 reference

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4 November 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797537%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

147-161

1 reference

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https://scigraph.springernature.com/pub.10.1023/a:1023381027062

4 November 2019

exact match

0 references

cites work

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

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12 December 2020

Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression

1 reference

12 December 2020

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

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12 December 2020

A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells

1 reference

12 December 2020

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

1 reference

12 December 2020

An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3.

1 reference

12 December 2020

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

1 reference

12 December 2020

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

1 reference

12 December 2020

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

1 reference

12 December 2020

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

1 reference

12 December 2020

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene

1 reference

12 December 2020

Mutation of Tec family kinases alters T helper cell differentiation

1 reference

12 December 2020

The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation

1 reference

12 December 2020

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

1 reference

12 December 2020

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1 reference

12 December 2020

Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

1 reference

12 December 2020

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

1 reference

12 December 2020

Immunologic basis of antigen-induced airway hyperresponsiveness

1 reference

12 December 2020

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

1 reference

12 December 2020

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

1 reference

12 December 2020

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

1 reference

12 December 2020

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

1 reference

12 December 2020

The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells.

1 reference

12 December 2020

A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5

1 reference

12 December 2020

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

12 December 2020

Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells

1 reference

12 December 2020

Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s

1 reference

12 December 2020

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression

1 reference

12 December 2020

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

1 reference

12 December 2020

Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4.

1 reference

12 December 2020

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

12 December 2020

An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex

1 reference

12 December 2020

A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

1 reference

12 December 2020

Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells

1 reference

12 December 2020

Transcription factor GATA-3 is required for development of the T-cell lineage

1 reference

12 December 2020

Gene silencing quantitatively controls the function of a developmental trans-activator

1 reference

12 December 2020

T helper subset development: roles of instruction, selection, and transcription

1 reference

12 December 2020

GATA-3-dependent enhancer activity in IL-4 gene regulation

1 reference

12 December 2020

Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression

1 reference

12 December 2020

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.

1 reference

12 December 2020

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

1 reference

12 December 2020

Interferon gamma stabilizes the T helper cell type 1 phenotype.

1 reference

12 December 2020

Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile

1 reference

12 December 2020

TSLP: finally in the limelight

1 reference

12 December 2020

Reduced IFNgamma production in response to IL-12 stimulation and/or reduced IL-12 production in atopic patients

1 reference

12 December 2020

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor

1 reference

12 December 2020

Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells

1 reference

12 December 2020

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

1 reference

12 December 2020

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

1 reference

12 December 2020

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer

1 reference

12 December 2020

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1 reference

12 December 2020

GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer

1 reference

12 December 2020

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1 reference

12 December 2020

Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses

1 reference

12 December 2020

Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4

1 reference

12 December 2020

Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation

1 reference

12 December 2020

Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation

1 reference

12 December 2020

Inherited disorders of IL-12- and IFNγ-mediated immunity: a molecular genetics update

1 reference

12 December 2020

Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function

1 reference

12 December 2020

Regulation of T(H)1 differentiation--controlling the controllers

1 reference

12 December 2020

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

1 reference

12 December 2020

IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites

1 reference

12 December 2020

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

1 reference

12 December 2020

Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for a GATA-binding protein.

1 reference

12 December 2020

Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1

1 reference

12 December 2020

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

1 reference

12 December 2020

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1 reference

12 December 2020

Alloantigen-reactive Th1 development in IL-12-deficient mice

1 reference

12 December 2020

BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling

1 reference

12 December 2020

Deletion of a coordinate regulator of type 2 cytokine expression in mice

1 reference

12 December 2020

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands

1 reference

12 December 2020

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation

1 reference

12 December 2020

Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

1 reference

12 December 2020

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans

1 reference

12 December 2020

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 reference

12 December 2020

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

1 reference

12 December 2020

Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

1 reference

12 December 2020

Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

1 reference

12 December 2020

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

1 reference

12 December 2020

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

1 reference

12 December 2020

Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion

1 reference

12 December 2020

The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease

1 reference

12 December 2020

Embryonic expression and cloning of the murine GATA-3 gene

1 reference

12 December 2020

Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo

1 reference

12 December 2020

The Maf transcription factors: regulators of differentiation

1 reference

12 December 2020

1 reference

12 December 2020

IFN-gamma production by antigen-presenting cells: mechanisms emerge.

1 reference

12 December 2020

Transcription: tantalizing times for T cells

1 reference

12 December 2020

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production

1 reference

12 December 2020

Lineage commitment in lymphocytes: controlling the immune response

1 reference

12 December 2020

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

1 reference

12 December 2020

T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling

1 reference

12 December 2020

Cloning and characterization of a mouse IL-12 receptor-beta component.

1 reference

12 December 2020

Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling

1 reference

12 December 2020

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

1 reference

12 December 2020

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

1 reference

12 December 2020

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

1 reference

12 December 2020

SAP controls T cell responses to virus and terminal differentiation of TH2 cells.

1 reference

12 December 2020

Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.

1 reference

12 December 2020

Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99

1 reference

12 December 2020

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

12 December 2020

Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity

1 reference

12 December 2020

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

1 reference

12 December 2020

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

1 reference

12 December 2020

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

1 reference

12 December 2020

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

1 reference

12 December 2020

Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells

1 reference

12 December 2020

c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms

1 reference

12 December 2020

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

12 December 2020

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

1 reference

12 December 2020

Molecular events involved in regulating human interferon-gamma gene expression during T cell activation

1 reference

12 December 2020

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

12 December 2020

Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development

1 reference

12 December 2020

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

1 reference

12 December 2020

Partial impairment of cytokine responses in Tyk2-deficient mice

1 reference

12 December 2020

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1 reference

12 December 2020

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

1 reference

12 December 2020

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

1 reference

12 December 2020

Structure and specificity of GATA proteins in Th2 development

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

12 December 2020

A novel transcription factor, T-bet, directs Th1 lineage commitment

1 reference

12 December 2020

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

1 reference

12 December 2020

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

1 reference

12 December 2020

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

1 reference

12 December 2020

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

1 reference

12 December 2020

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

1 reference

12 December 2020

The role of Stat4 in species-specific regulation of Th cell development by type I IFNs.

1 reference

12 December 2020

The biology of Stat4 and Stat6

1 reference

12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

12 December 2020

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo

1 reference

12 December 2020

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo

1 reference

12 December 2020

Functional diversity of helper T lymphocytes

1 reference

12 December 2020

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

1 reference

12 December 2020

Atopy and mutations of IL-12 receptor beta 2 chain gene

1 reference

12 December 2020

The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression

1 reference

12 December 2020

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

1 reference

12 December 2020

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

12 December 2020

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

1 reference

12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

12 December 2020

Helper T cells regulate type-2 innate immunity in vivo

1 reference

12 December 2020

Interleukin-12: basic principles and clinical applications.

1 reference

12 December 2020

A critical role for IL-21 in regulating immunoglobulin production

1 reference

12 December 2020

Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster

1 reference

12 December 2020

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

1 reference

12 December 2020

The IL-4 receptor: signaling mechanisms and biologic functions

1 reference

12 December 2020

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

1 reference

12 December 2020

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

12 December 2020

Identification of IL-4 promoter elements conferring Th2-restricted expression during T helper cell subset development

1 reference

12 December 2020

Molecular mechanisms regulating Th1 immune responses

1 reference

12 December 2020

Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene

1 reference

12 December 2020

Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells.

1 reference

12 December 2020

Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma

1 reference

12 December 2020

ROG, repressor of GATA, regulates the expression of cytokine genes

1 reference

12 December 2020

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1 reference

12 December 2020

Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M

1 reference

12 December 2020

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family

1 reference

12 December 2020

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1 reference

12 December 2020

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

1 reference

12 December 2020

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

1 reference

12 December 2020

IL-23: a cytokine that acts on memory T cells

1 reference

12 December 2020

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

1 reference

12 December 2020

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

1 reference

12 December 2020

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

1 reference

12 December 2020

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

1 reference

12 December 2020

Dendritic cell lineage, plasticity and cross-regulation

1 reference

12 December 2020

Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions

1 reference

12 December 2020

Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation

1 reference

12 December 2020

Signaling and transcription in T helper development

1 reference

12 December 2020

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

1 reference

12 December 2020