(Q35154720)

6 August 2017

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism (English)

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6 August 2017

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parkinsonian syndrome

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Veronica Francardo

1

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Tadeusz Wieloch

object named as

Tadeusz Wieloch

3

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Francesco Bez

2

object named as

Francesco Bez

1 reference

6 August 2017

M. Angela Cenci Nilsson

6

object named as

M Angela Cenci

1 reference

6 August 2017

Hans Nissbrandt

4

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6 August 2017

Karsten Ruscher

5

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6 August 2017

language of work or name

English

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publication date

22 April 2014

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6 August 2017

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6 August 2017

137

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6 August 2017

1998-2014

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6 August 2017

Pt 7

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Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats.

6 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Somatodendritic dopamine release in rat substantia nigra influences motor performance on the accelerating rod.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Stepping test in mice: a reliable approach in determining forelimb akinesia in MPTP-induced Parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Mitochondrial Ca(2+) and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Animal models of neurological deficits: how relevant is the rat?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Glial cell line-derived neurotrophic factor promotes the arborization of cultured striatal neurons through the p42/p44 mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Intracellular Dynamics of σ-1 Receptors (σ1Binding Sites) in NG108-15 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

σ-1 Receptors (σ1Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

The sigma-1 receptor: roles in neuronal plasticity and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Does contraversive circling in the 6-OHDA-lesioned rat indicate an ability to induce motor complications as well as therapeutic effects in Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1R agonist improves motor function and motoneuron survival in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

The pharmacology of sigma-1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Low density of sigma1 receptors in early Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke: influence of enriched environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1 receptor knockout mice display a depressive-like phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

The cholinergic system, sigma-1 receptors and cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU107

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWU107

1 reference

6 August 2017

1 reference