(Q35157119)

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20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24763529%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616 (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24763529%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

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phosphorylation

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5

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15 March 2020

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Xuguang Li

1

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15 March 2020

Gang Zhao

2

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15 March 2020

Ben Ma

3

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15 March 2020

Rui Li

4

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15 March 2020

Shaowen Liu

6

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15 March 2020

Dao Wen Wang

7

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15 March 2020

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24 April 2014

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15 March 2020

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Europe PubMed Central

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15 March 2020

9

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15 March 2020

4

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15 March 2020

e95841

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15 March 2020

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Creative Commons Attribution 4.0 International

24 April 2014

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20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat.

1 reference

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13 July 2018

Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Inhibition of 20-HETE attenuates diabetes-induced decreases in retinal hemodynamics

1 reference

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13 July 2018

Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice

1 reference

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13 July 2018

Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive protein.

1 reference

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13 July 2018

Oxidative stress and diabetic complications

1 reference

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13 July 2018

20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling

1 reference

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13 July 2018

eNOS, metabolic syndrome and cardiovascular disease.

1 reference

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13 July 2018

Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Phosphorylation of IRS proteins, insulin action, and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

1 reference

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13 July 2018

20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Cardiovascular actions of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Inflammation and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

13 July 2018

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

1 reference

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13 July 2018

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3998975

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Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

1 reference

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Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

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1 reference

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1 reference

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Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery.

1 reference

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Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke

1 reference

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Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells

1 reference

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1 reference

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12 December 2020

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10.1371/JOURNAL.PONE.0095841

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24763529%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

2014PLoSO...995841L

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Europe PubMed Central

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15 March 2020

PubMed publication ID

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Europe PubMed Central

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15 March 2020

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