(Q35159124)

English

The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review

scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

1 reference

Europe PubMed Central

The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

David Gustafsson

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Margareta Elg

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

publication date

1 July 2003

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Thrombosis Research

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

109 Suppl 1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

S9-15

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range

1 reference

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7 January 2021

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Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Small, noncovalent serine protease inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Thrombin inhibitors based on ketone derivatives of arginine and lysine

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro effects of inogatran, a selective low molecular weight thrombin inhibitor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Animal pharmacokinetics of inogatran, a low-molecular-weight thrombin inhibitor with potential use as an antithrombotic drug

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A low molecular weight, selective thrombin inhibitor, inogatran, vs heparin, in unstable coronary artery disease in 1209 patients. A double-blind, randomized, dose-finding study. Thrombin inhibition in Myocardial Ischaemia (TRIM) study group

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, and dalteparin on the endogenous thrombin potential in venous blood from healthy male subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Thrombin-induced platelet activation and its inhibition by anticoagulants with different modes of action

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of different types of thrombin inhibitors on thrombin/thrombomodulin modulated activation of protein C in vitro

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

New anticoagulant drugs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A randomized, controlled, dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute deep vein thrombosis: THRIVE I.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of ximelagatran, the oral form of melagatran, in the treatment of caval vein thrombosis in conscious rats

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The effects of oral and intravenous direct thrombin inhibitors on the size of photochemically induced cortical infarction in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Acute antithrombotic effects of ximelagatran, an oral direct thrombin inhibitor, and r-hirudin in a human ex vivo model of arterial thrombosis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis for the resistance of fibrin-bound thrombin to inactivation by heparin/serpin complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Trial of different intensities of anticoagulation in patients with prosthetic heart valves.

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of activated prothrombin complex concentrate or recombinant factor VIIa on the bleeding time and thrombus formation during anticoagulation with a direct thrombin inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of agents, used to treat bleeding disorders, on bleeding time prolonged by a very high dose of a direct thrombin inhibitor in anesthesized rats and rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

No Influence of Obesity on the Pharmacokinetics and Pharmacodynamics of Melagatran, the Active Form of the Oral Direct Thrombin Inhibitor Ximelagatran

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

No Influence of Ethnic Origin on the Pharmacokinetics and Pharmacodynamics of Melagatran Following Oral Administration of Ximelagatran, a Novel Oral Direct Thrombin Inhibitor, to Healthy Male Volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Dalteparin: an update of its pharmacological properties and clinical efficacy in the prophylaxis and treatment of thromboembolic disease

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran: a population model analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study

1 reference

https://api.crossref.org/works/10.1016%2FS0049-3848%2803%2900249-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability, and safety study

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0049-3848(03)00249-4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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