(Q35160784)

6 August 2017

title

Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions (English)

1 reference

6 August 2017

Michael D Diem

1

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6 August 2017

Linus Hyun

2

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6 August 2017

Fang Yi

3

1 reference

6 August 2017

Randi Hippensteel

4

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6 August 2017

Elise Kuhar

5

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6 August 2017

Cassandra Lowenstein

6

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6 August 2017

Edward J Swift

7

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6 August 2017

Karyn T O'Neil

8

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6 August 2017

Steven A Jacobs

9

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6 August 2017

language of work or name

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30 April 2014

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Protein Engineering Design and Selection

6 August 2017

published in

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6 August 2017

volume

27

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6 August 2017

issue

10

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6 August 2017

page(s)

419-429

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Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

6 August 2017

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Folding of beta-sandwich proteins: three-state transition of a fibronectin type III module

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The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer

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Simple method for production of randomized human tenth fibronectin domain III libraries for use in combinatorial screening procedures.

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A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces

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Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity

21 January 2018

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Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling

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Design of novel FN3 domains with high stability by a consensus sequence approach

21 January 2018

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Molecular recognition properties of FN3 monobodies that bind the Src SH3 domain

21 January 2018

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The fibronectin type III domain as a scaffold for novel binding proteins

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High-affinity single-domain binding proteins with a binary-code interface

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Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

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Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

21 January 2018

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Engineering proteins for thermostability: the use of sequence alignments versus rational design and directed evolution

21 January 2018

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The consensus concept for thermostability engineering of proteins

21 January 2018

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Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies

21 January 2018

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Stabilizing ionic interactions in a full-consensus ankyrin repeat protein

21 January 2018

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Context-dependent mutations predominate in an engineered high-affinity single chain antibody fragment

21 January 2018

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CIS display: In vitro selection of peptides from libraries of protein-DNA complexes

21 January 2018

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mRNA display selection of a high-affinity, modification-specific phospho-IkappaBalpha-binding fibronectin

21 January 2018

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Antibody mimics based on human fibronectin type three domain engineered for thermostability and high-affinity binding to vascular endothelial growth factor receptor two.

21 January 2018

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Recombinant protein therapeutics--success rates, market trends and values to 2010.

21 January 2018

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Structures of adnectin/protein complexes reveal an expanded binding footprint

21 January 2018

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Monoclonal antibodies market

21 January 2018

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Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin

21 January 2018

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A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition

21 January 2018

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Antibody therapeutics in cancer.

21 January 2018

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Consensus-based engineering of protein stability: from intrabodies to thermostable enzymes.

21 January 2018

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Engineering of phytase for improved activity at low pH.

21 January 2018

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A novel solid phase technology for high-throughput gene synthesis.

21 January 2018

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A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

21 January 2018

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Directed evolution of high-affinity antibody mimics using mRNA display

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/PROTEIN/GZU016

1 reference

6 August 2017

1 reference