(Q35163318)

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Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals

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scholarly article

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6 August 2017

Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals (English)

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Europe PubMed Central

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6 August 2017

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vector-borne disease

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malaria vaccine

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based on heuristic

inferred from title

24

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Sarah C Gilbert

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Katharine A Collins

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Katharine A Collins

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Nick J Edwards

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Georgina Bowyer

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Georgina Bowyer

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Rhea Longley

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Alexander D Douglas

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Alexander D Douglas

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Stephen Gerry

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Susanne H Hodgson

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Susanne H Hodgson

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Saul N Faust

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Philip Bejon

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6 August 2017

Adrian V. S. Hill

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Adrian V S Hill

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Katie J Ewer

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Alison M. Lawrie

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Alison M Lawrie

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Eleanor Berrie

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Carly M Bliss

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Ian D Poulton

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Thomas W Rampling

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Thomas Rampling

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Nicholas A Anagnostou

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Nicholas A Anagnostou

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Eoghan de Barra

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Eoghan de Barra

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Simone C de Cassan

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Simone de Cassan

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Joseph J Illingworth

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Joseph J Illingworth

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Pooja B Mange

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Stefano Colloca

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Stefano Colloca

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Alfredo Nicosia

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Alfredo Nicosia

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Robert E Sinden

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Robert E Sinden

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6 August 2017

author name string

Tom Havelock

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Rachel Roberts

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Sarah Moyle

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Riccardo Cortese

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publication date

21 October 2014

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6 August 2017

Journal of Infectious Diseases

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6 August 2017

211

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7

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6 August 2017

1076-1086

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6 August 2017

Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

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Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunities

1 reference

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28 July 2018

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure

1 reference

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28 July 2018

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity

1 reference

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28 July 2018

A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

1 reference

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28 July 2018

Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector

1 reference

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28 July 2018

Preventing spontaneous genetic rearrangements in the transgene cassettes of adenovirus vectors

1 reference

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28 July 2018

Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity

1 reference

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28 July 2018

Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D)

1 reference

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28 July 2018

Protective immunity to pre-erythrocytic stage malaria

1 reference

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28 July 2018

Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

1 reference

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28 July 2018

Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

1 reference

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28 July 2018

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update

1 reference

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28 July 2018

A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

1 reference

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28 July 2018

Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.

1 reference

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Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein

1 reference

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Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara

1 reference

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Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

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The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Sporozoite vaccine induces genetically restricted T cell elimination of malaria from hepatocytes

1 reference

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Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

28 July 2018

Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4354983

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Malaria vaccine technology roadmap

1 reference

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27 September 2018

1 reference

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Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection

1 reference

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Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data

1 reference

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

1 reference

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Experimental human challenge infections can accelerate clinical malaria vaccine development

1 reference

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Prime-boost vectored malaria vaccines: progress and prospects

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Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens, ME-TRAP or the circumsporozoite protein, in children and adults in Kenya

1 reference

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Enhanced protective immunity against malaria by vaccination with a recombinant adenovirus encoding the circumsporozoite protein of Plasmodium lacking the GPI-anchoring motif

1 reference

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Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+ cytotoxic T-cell clone recognizing sporozoite surface protein 2.

1 reference

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27 September 2018

Identifiers

10.1093/INFDIS/JIU579

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Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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