(Q35172779)

6 August 2017

1 reference

title

Why did p53 gene therapy fail in ovarian cancer? (English)

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6 August 2017

0 references

1 reference

Alain G Zeimet

1

1 reference

PubMed ID

12850192

6 August 2017

Christian Marth

series ordinal

2

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6 August 2017

1 July 2003

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Lancet Oncology Commission

6 August 2017

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6 August 2017

4

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6 August 2017

415-422

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6 August 2017

7

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New insights into p53 regulation and gene therapy for cancer.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

1 reference

7 January 2021

Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Switching from life to death: the Miz-ing link between Myc and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Mechanism of the combination effect of wild-type TP53 gene transfection and cisplatin treatment for ovarian cancer xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Effect of p53 status on sensitivity to platinum complexes in a human ovarian cancer cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

p53 Gene therapy for lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Genetic and immunologic therapies for lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Genetic mechanisms of tumor suppression by the human p53 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Analysis of p73 in human borderline and invasive ovarian tumor

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

In vivo studies of adenovirus-based p53 gene therapy for ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Effect of p53 gene transfer and cisplatin in a peritonitis carcinomatosa model with p53-deficient ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domain

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Optimizing suicide gene therapy for head and neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Adenoviral transduction efficiency of ovarian cancer cells can be limited by loss of integrin beta3 subunit expression and increased by reconstitution of integrin alphavbeta3.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Integrin alpha(v)beta1 is an adenovirus coreceptor

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Efficient destruction of human immunodeficiency virus in human serum by inhibiting the protective action of complement factor H and decay accelerating factor (DAF, CD55).

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

The effects of the adenovirus-mediated wild-type p53 delivery in human epithelial ovarian cancer cell line in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Adenoviral vector-mediated gene transfer for human gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

Transcriptional targeting for ovarian cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2803%2901139-2

7 January 2021

10.1016/S1470-2045(03)01139-2

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12850192