(Q35180670)

7 August 2017

title

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions (English)

1 reference

Shina Caroline Lynn Kamerlin

7 August 2017

author

series ordinal

3

object named as

Shina C L Kamerlin

1 reference

7 August 2017

4

Arieh Warshel

1 reference

7 August 2017

Andrew J Adamczyk

1

1 reference

7 August 2017

Jie Cao

series ordinal

2

1 reference

7 August 2017

language of work or name

English

0 references

publication date

10 August 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

published in

1 reference

7 August 2017

volume

108

1 reference

7 August 2017

issue

34

1 reference

7 August 2017

page(s)

14115-14120

1 reference

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

7 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Protein dynamics and enzyme catalysis: insights from simulations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

The role of conformational entropy in molecular recognition by calmodulin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

The energetics of the primary proton transfer in bacteriorhodopsin revisited: it is a sequential light-induced charge separation after all

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

On the relationship between thermal stability and catalytic power of enzymes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Minimalist active-site redesign: teaching old enzymes new tricks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Dynamical contributions to enzyme catalysis: critical tests of a popular hypothesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

New tools provide new insights in NMR studies of protein dynamics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Structure, dynamics, and catalytic function of dihydrofolate reductase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

How important are entropic contributions to enzyme catalysis?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

28 July 2018

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Dynamics of enzymatic reactions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Electrostatic Energy and Macromolecular Function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Energetics of enzyme catalysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Hidden alternative structures of proline isomerase essential for catalysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Enzyme millisecond conformational dynamics do not catalyze the chemical step

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Dynamic activation of protein function: a view emerging from NMR spectroscopy.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Redistribution and loss of side chain entropy upon formation of a calmodulin-peptide complex

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161549

Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1111252108

Dispersed polaron simulations of electron transfer in photosynthetic reaction centers

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21831831

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21831831

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1111252108

1 reference

7 August 2017

0 references

1 reference

7 August 2017

1 reference